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- Oct 22, 2010
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I saw that article. I am going to tamp down my enthusiasm, but it does look promising. I think this would be the first mRNA vaccine ever approved, right? The concept of mRNA vaccines is hella cool and eliminates some of the concerns with attenuated virus or protein antigen based vaccines. Keeping my fingers crossed.Moderna vaccine Phase I results just been published in NEJM. Look pretty good too. Bumped their share price 16%.
"The mRNA-1273 vaccine induced anti–SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified."Moderna vaccine Phase I results just been published in NEJM. Look pretty good too. Bumped their share price 16%.
https://www.phgfoundation.org/briefing/rna-vaccinesI saw that article. I am going to tamp down my enthusiasm, but it does look promising. I think this would be the first mRNA vaccine ever approved, right? The concept of mRNA vaccines is hella cool and eliminates some of the concerns with attenuated virus or protein antigen based vaccines. Keeping my fingers crossed.
my old PI worked on targeted RNA therapies and he quoted eye-watering prices for a single dose. i'm not 100% sure why the manufacturing is so difficult - it cn't be just making the sequence itself - but i wonder if that will change for the massive mass production this might require.I saw that article. I am going to tamp down my enthusiasm, but it does look promising. I think this would be the first mRNA vaccine ever approved, right? The concept of mRNA vaccines is hella cool and eliminates some of the concerns with attenuated virus or protein antigen based vaccines. Keeping my fingers crossed.
I believe that rna vaccines are theoretically cheaper and faster to produce when scaled up. I'd guess the high price is because we have never done this yet.my old PI worked on targeted RNA therapies and he quoted eye-watering prices for a single dose. i'm not 100% sure why the manufacturing is so difficult - it cn't be just making the sequence itself - but i wonder if that will change for the massive mass production this might require.
I don’t even think production will be an issue. I look at the price of custom oligo production when I got to grad school in 2002, it’s not even close to the same.I believe that rna vaccines are theoretically cheaper and faster to produce when scaled up. I'd guess the high price is because we have never done this yet.
More a crazy storage facility than a Twitter thread.Tweet
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the replies.. good lord!
Sounds good! Is this the same sort of approach the Imperial vaccine is based on as well?"The mRNA-1273 vaccine induced anti–SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified."
"The US health system is so bad that people easily die of a common cold."Kinda looking forward to the emerging theories as to why all these people are dying in Texas, Florida, etc, given the virus doesn't exist.
Offices should be putting in place social distancing measures is the main reason i think. There's a big difference between wearing one for a brief shop visit where social distancing isn't possible and all day at your desk when you're already 2 metres apart.How is an enclosed office environment different from a shop environment?
Coronavirus: Matt Hancock rejects face coverings for offices
https://www.bbc.co.uk/news/uk-53415030
But saying the US health system is substantially worse at dealing with the common cold this year, in a number of red states, doesn't really give the message they're looking for - that Democrats are making this up to affect the election."The US health system is so bad that people easily die of a common cold."
That's not even outlandish.
I know. But there is no way out of it, either the virus is real or the US health system is shoddy or both. The Trumprites don't realize that they are not helping their cause with their nonsense.But saying the US health system is substantially worse at dealing with the common cold this year, in a number of red states, doesn't really give the message they're looking for - that Democrats are making this up to affect the election.
Like, it basically has to be that Dems are killing people?
The absolute egos on these people that the whole world would shut down their economies for months just to target republicans and their president. A group who make up less than 1% of the world's population.Tweet
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the replies.. good lord!
"If it wasn't for Obamacare and the Dems blocking Trumps wonder drugs we'd have saved them all".I know. But there is no way out of it, either the virus is real or the US health system is shoddy or both. The Trumprites don't realize that they are not helping their cause with their nonsense.
I think the Imperial vaccine is an rna vaccine but I don't know how similar it is to the one reported on here.Sounds good! Is this the same sort of approach the Imperial vaccine is based on as well?
They have already had to come up with a change of narrative to explain why it's not only happening in 'Dem states' now. Mental gymnastics worthy of olympic medals.But saying the US health system is substantially worse at dealing with the common cold this year, in a number of red states, doesn't really give the message they're looking for - that Democrats are making this up to affect the election.
Like, it basically has to be that Dems are killing people?
There is big difference and it’s not one that supports wearing them in shops over wearing them in offices.Offices should be putting in place social distancing measures is the main reason i think. There's a big difference between wearing one for a brief shop visit where social distancing isn't possible and all day at your desk when you're already 2 metres apart.
Tweet
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The first comment is relieved that transparency will finally be served.Tweet
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I just want to know if hospitals can just say “feck you” and send it to the CDC anyway?The first comment is relieved that transparency will finally be served.
Trump finds a replacement for Fauci...Next Monday there will be zero cases and announcment he has defeated the virus
I’m torn between excitement and the knowledge that a lot of Americans will either refuse to have it or possibly won’t be able to afford it.https://www.nejm.org/doi/full/10.1056/NEJMoa2022483
Looks like a vaccine developed in the US works. Phase1 open label trial
New England Journal of Medicine
ORIGINAL ARTICLE
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
List of authors.
July 14, 2020
- Lisa A. Jackson, M.D., M.P.H.,
- Evan J. Anderson, M.D.,
- Nadine G. Rouphael,
DOI: 10.1056/NEJMoa2022483
Abstract
BACKGROUND
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine. The candidate vaccine mRNA-1273 encodes the stabilized prefusion SARS-CoV-2 spike protein.
METHODS
We conducted a phase 1, dose-escalation, open-label trial including 45 healthy adults, 18 to 55 years of age, who received two vaccinations, 28 days apart, with mRNA-1273 in a dose of 25 μg, 100 μg, or 250 μg. There were 15 participants in each dose group.
RESULTS
After the first vaccination, antibody responses were higher with higher dose (day 29 enzyme-linked immunosorbent assay anti–S-2P antibody geometric mean titer [GMT], 40,227 in the 25-μg group, 109,209 in the 100-μg group, and 213,526 in the 250-μg group). After the second vaccination, the titers increased (day 57 GMT, 299,751, 782,719, and 1,192,154, respectively). After the second vaccination, serum-neutralizing activity was detected by two methods in all participants evaluated, with values generally similar to those in the upper half of the distribution of a panel of control convalescent serum specimens. Solicited adverse events that occurred in more than half the participants included fatigue, chills, headache, myalgia, and pain at the injection site. Systemic adverse events were more common after the second vaccination, particularly with the highest dose, and three participants (21%) in the 250-μg dose group reported one or more severe adverse events.
CONCLUSIONS
The mRNA-1273 vaccine induced anti–SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified. These findings support further development of this vaccine. (Funded by the National Institute of Allergy and Infectious Diseases and others; mRNA-1273 ClinicalTrials.gov number, NCT04283461. opens in new tab)
Its sad for the children who will miss out because of moronic parents but I have little to no sympathy for adults who will succumb to their own ignorance.I’m torn between excitement and the knowledge that a lot of Americans will either refuse to have it or possibly won’t be able to afford it.
Excited for the rest of y’all though.