Cool. Very little to nit-pick there (other than lowish number of subjects). A well designed, well executed study. Using a different adenovirus for second dose makes a lot of sense and might explain excellent efficacy. These are arguably the most impressive results to date.
As I just said on the main thread, this is following all the disaster movie tropes. Just when the end of our ordeal is in sight... Boom! Vaccine resistant new variant!
Good luck Penna.
All the best Penna, hope everything works out for you x
I wouldn't know who to believe at the moment. Lombardy today said they should be able to do the whole region by June, and we have brought the start date for over 80s forward by a month. You might find that date comes forward.
That sounds hopeful. All the best with it.
That's another good news story and we need some of those. I suspect it's going to irritate a many people as it pleases, given that we're getting another efficacy result that appears to make a different dosing regime (in this case a single dose!) work better than the intended two dose pattern. It's certainly going to meet a lot of scepticism and cynical responses.
Good stuff. By the time May comes round there will have been millions of vaccinations with whatever version you're offered, if there have been no problems similar to the ones you had all those years ago it will be looking good. You will have to keep safe meanwhile though, even if restrictions are reduced for everyone else.
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Also, 100% effective at preventing hospitalisation after 22 days.
That thread is very promising, especially the analysis that the vaccine reduces transmission.
I'm thinking the same, fingers crossed.
Phew!
Yes it does help so thanks for sharing. And best of luck with the jab.
I don't really get it? It's not like we're in a situation where we can be overly fussy. Is this more about managing demand for a vaccine where supplies are short for the time being?
Wonder what they are going to use to rollout to 80 plus, the shielding and care homes. Logistically Pfizer is a nightmare which is why we’ve let the GPs with Oxford handle them.
For elderly in the community they can get them to travel to community vaccination hubs.
Ah Moderna is easier logistically I believe not that we have any yet! On Pfizer the advice changed last minute because initially our rollout plan was care homes first but one week before Pfizer arrived it was stated you couldn’t move the vaccine after delivery. I think a few weeks later that changed back to say you could and they did a pilot in North Wales but we’d already started on staff and with Oxford about to arrive decided to leave that to GPs. Hopefully it works on the elderly...
Is there a chance they’re all using it as an excuse to get a vaccine out into lower priority demographics? Pfizer/Moderna to the over 65s and in parallel they get to roll out a vaccine to more mobile age groups?
That’s interesting. I’m almost certain that care home residents got Pfizer as well as Moderna. Probably made life easier that we started a bit later so the advice re moving after delivery was already clear by then.
Not sure what news you’re expecting considering the first person on the planet to be vaccinated got their initial jab less than 8 weeks ago!
What news were you expecting? It hasn't even been 12 weeks since the 1st person anywhere received their pfizer vaccine and the news has been filled since then with undignified spats between the EU and pharmaceutical companies, vaccine nationalism, new variants, Northern Ireland, the EMA and AZ, continuing horrible numbers and promising new vaccine candidates.
How does this make sense, if the initial results said the vaccine was only 62% effective after 2 jabs? Yet it's 76% effective after one jab?
Italy has already done most of the care home residents with Pfizer, so it is possible. My region is scheduled to finish first and second doses by 23 February.
I like this news. I believe most of the other vaccines do not reduce transmission?
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Most (all?) of the other studies didn’t check. They only did PCR tests when clinically indicated (i.e. when symptomatic)
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As well as the other vaccines, the AZ one could still end up with decent evidence in the elderly. They’ve a phase 3 study which is recruiting elderly subjects that started after the studies used to get the license. If that generates some decent results then all those recommendations could change.
The odds must be high that they will.
