The vaccines | vaxxed boosted unvaxxed? New poll

How's your immunity looking? Had covid - vote twice - vax status and then again for infection status

  • Vaxxed but no booster

  • Boostered

  • Still waiting in queue for first vaccine dose

  • Won't get vaxxed (unless I have to for travel/work etc)

  • Past infection with covid + I've been vaccinated

  • Past infection with covid - I've not been vaccinated


Results are only viewable after voting.

forevrared

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Had Moderna shot #1 yesterday. A bit of a sore arm, but went on a 5 mile hike immediately after and felt fine throughout. Feel fine today, little residual soreness but only if I go poking the injection site.
As I understand it though, it’s the 2nd one that gets you.
 

berbatrick

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Dunno if you saw my previous response but a sudden large bruise at the injection site wouldn’t worry me at all. It’s easy enough to nick a blood vessel giving the elderly (or middle-aged) an IM injection. Timing is important too. The coagulopathy is immune mediated, so will take a while to kick in. A punctured blood vessel will give a big old bruise in < 24 hours.
thanks, i'll ask about timing.
 

TheReligion

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Classical Mechanic

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VMIC got its funding approval in 2019, with an intention of being ready to manufacture (from clinical trial quantity through to production quantity) a couple of different vaccine types. Basically an acknowledgment that there was no spare capacity in the vaccine production plants and a pooled resource for trials work was important as there's not (normally) much money in the vaccine business. It also got some funding as a a result of one of those NHS pandemic preparedness reviews that identified the lack of surge capacity as an issue.

It was expected to come online sometime in 2022, but got some serious fasttrack funding due to covid. They recruited staff early and bought the manufacturing kit before they had premises and they started building the labs and the factory unit before they had formal planning consent from the local authority for example.

I've read their kit and their new staff have been making AZ in borrowed premises, for the last few months, pending completion of their own permanent buildings. So they're kind of starting now really.
Thanks. Did managed to find some details as well. Should be officially open in summer and will be used for the vaccine updates. Hope to be able to make enough for the whole country in a 4-6 month time frame. Not really clear if we can make them completely on these shores though.
 
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mav_9me

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I haven't looked into the details - is the fatal clotting happening after the first or second shot (or both)? I am very concerned about my mother's sudden bruise after the first shot, but she and her doctor don't seem to be.
Bruising at the site of injection is not unexpected. Bruising or bleeding elsewhere would be the thing to look for
 

jojojo

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Thanks. Did managed to find some details as well. Should be officially open in summer and will be used for the vaccine updates. Hope to be able to make enough for the whole country in a 4-6 month time frame. Not really clear if we can make them completely on these shores though.
Yep, they're maybe 12/18 months ahead of where they were expecting in terms of their own facility.

Making a (high volume) vaccine completely is more or less an impossibility these days. The equipment, the chemical reagents and precursors are just too specialised for every country to have all of the facilities - even if they could store the basic chemicals indefinitely.

The US and China probably get closest, though they of course rely on ingredients that are not available locally.

India has massive vaccine production capacity, but are currently limited on how much vaccine they can produce by the US export block. That doesn't just stop complete vaccines leaving the US, it also stops some reagents and basic manufacturing kit (like the disposable bioreactor bags and certain kids of plastic tubing) being exported.

Even things like glass vials, syringes and bottle caps have been production bottle necks, as the supply chains get overwhelmed.

I've read that the simplest vaccines to produce (in terms of the equipment and the number of basic chemicals involved) are actually the mRNAs - though I don't know enough to know if that's true :smirk: . But the handling side (fragile chemicals that require special handling and a tricky cold chain) means that you need to have the right factory.
 

langster

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People need to really be wary of spreading misinformation about this.
Indeed they do. I'm booked in to have mine today at 1:30 and I was a little hesitant as I mentioned earlier in this thread, but also excited in a strange way too.

Now after reading all this about blood clots and brain issues and headaches etc, I am absolutely fecking petrified.

I know it's probably highly irrational, but after having a subarachnoid hemorrhage (anuerysm) I must say the last dozen or so pages haven't helped my fear. I know that the risk is miniscule and might not even be related to the vaccine, but the worry is still there.
 

Norman Brownbutter

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Indeed they do. I'm booked in to have mine today at 1:30 and I was a little hesitant as I mentioned earlier in this thread, but also excited in a strange way too.

Now after reading all this about blood clots and brain issues and headaches etc, I am absolutely fecking petrified.

I know it's probably highly irrational, but after having a subarachnoid hemorrhage (anuerysm) I must say the last dozen or so pages haven't helped my fear. I know that the risk is miniscule and might not even be related to the vaccine, but the worry is still there.
I was where you are now, mate, three weeks ago. Panic stations because of all the shit being said around the internet. Only comfort I can offer is that aside from feeling a bit tired and a couple of little head aches every now and again, it was fine.
I won’t tell you not to worry, because it’s not like your subconscious will listen. But I will tell you it’ll be fine. Millions of people have taken it, and there’s only double figures of blood clotting issues. So that’s like lottery odds. So the chances of anything bad happening are pretty low. Best of luck, mate. Not that you’ll need it.
 

langster

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I was where you are now, mate, three weeks ago. Panic stations because of all the shit being said around the internet. Only comfort I can offer is that aside from feeling a bit tired and a couple of little head aches every now and again, it was fine.
I won’t tell you not to worry, because it’s not like your subconscious will listen. But I will tell you it’ll be fine. Millions of people have taken it, and there’s only double figures of blood clotting issues. So that’s like lottery odds. So the chances of anything bad happening are pretty low. Best of luck, mate. Not that you’ll need it.
Thanks mate.

I know I'm probably worrying for nothing. Appreciate the comforting reply. Thanks again.
 

berbatrick

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Dunno if you saw my previous response but a sudden large bruise at the injection site wouldn’t worry me at all. It’s easy enough to nick a blood vessel giving the elderly (or middle-aged) an IM injection. Timing is important too. The coagulopathy is immune mediated, so will take a while to kick in. A punctured blood vessel will give a big old bruise in < 24 hours.
She noticed it 4 days after her vaccine (AZ 1st dose), far from the injection site.
Very very worried. No other symptoms though. Her doctor says it's a vein burst, probably due to some physical injury. She's over 65 though so seems to be outside the reported range.
 

Bratt

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People need to really be wary of spreading misinformation about this.
Yeah, I’ll take that, and I apologise.
It wasn’t really misinformation though, only badly worded, as two people did die yesterday.
I should have written in that post that it wasn’t new cases, but two of the five already reported being hospitalised.
 

Wolverine

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https://www.bbc.co.uk/news/health-56479462
https://www.astrazeneca.com/media-c...ca-us-vaccine-trial-met-primary-endpoint.html

Good news regarding potential approval for AZ in the states, also with regards to safety from a coagulopathy point of view and efficacy in the elderly and those with comorbidities

The AstraZeneca US Phase III trial of AZD1222 demonstrated statistically significant vaccine efficacy of 79% at preventing symptomatic COVID-19 and 100% efficacy at preventing severe disease and hospitalisation.

This interim safety and efficacy analysis was based on 32,449 participants accruing 141 symptomatic cases of COVID-19. The trial had a 2:1 randomisation of vaccine to placebo. Approximately 20% of participants were 65 years and over, and approximately 60% had co-morbidities associated with an increased risk for progression of severe COVID-19, such as diabetes, severe obesity or cardiac disease.

Vaccine efficacy was consistent across ethnicity and age. Notably, in participants aged 65 years and over, vaccine efficacy was 80%.

The vaccine was well tolerated, and the independent data safety monitoring board (DSMB) identified no safety concerns related to the vaccine. The DSMB conducted a specific review of thrombotic events, as well as cerebral venous sinus thrombosis (CVST) with the assistance of an independent neurologist. The DSMB found no increased risk of thrombosis or events characterised by thrombosis among the 21,583 participants receiving at least one dose of the vaccine. The specific search for CVST found no events in this trial.
 

jojojo

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https://www.bbc.co.uk/news/health-56479462
https://www.astrazeneca.com/media-c...ca-us-vaccine-trial-met-primary-endpoint.html

Good news regarding potential approval for AZ in the states, also with regards to safety from a coagulopathy point of view and efficacy in the elderly and those with comorbidities
That's good news.

Reading some of the reports this past couple of weeks, it had started to feel like the good results in the rollout in the UK had to be due to a massive dose of the placebo effect.
 

Pogue Mahone

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https://www.bbc.co.uk/news/health-56479462
https://www.astrazeneca.com/media-c...ca-us-vaccine-trial-met-primary-endpoint.html

Good news regarding potential approval for AZ in the states, also with regards to safety from a coagulopathy point of view and efficacy in the elderly and those with comorbidities
Representative patient population. Everyone getting the same dose interval. That’s what a properly run study looks like. Could have saved everyone a load of hassle (and got FDA approval months earlier) if all their studies had followed that same protocol. Still, though, good news. For countries they are able to supply.
 

TheReligion

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Indeed they do. I'm booked in to have mine today at 1:30 and I was a little hesitant as I mentioned earlier in this thread, but also excited in a strange way too.

Now after reading all this about blood clots and brain issues and headaches etc, I am absolutely fecking petrified.

I know it's probably highly irrational, but after having a subarachnoid hemorrhage (anuerysm) I must say the last dozen or so pages haven't helped my fear. I know that the risk is miniscule and might not even be related to the vaccine, but the worry is still there.
Don't be worried. You're doing the right thing for sure and a bit if concern is far from irrational. Let us know how it goes and try and enjoy it. It's the first part of getting back to normality and you being protected and keeping good health. Not only that but protecting your loved ones and others loved ones.
 

lynchie

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Good news on headline efficacy for AZ. That was done with the 4 week gap for everyone, while I understand the 12 week gap results in higher antibody levels, so should be better. The US could be fully vaxed by May with the number of doses they have stockpiled, at which point I predict massive levels of vaccine diplomacy!
 

Stack

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Im sure its been explained somewhere but I seem to have missed it. Does anyone know how often we will have to take these vaccines? Yearly? Every 2 years or longer?
Cheers
 

jojojo

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Indeed they do. I'm booked in to have mine today at 1:30 and I was a little hesitant as I mentioned earlier in this thread, but also excited in a strange way too.

Now after reading all this about blood clots and brain issues and headaches etc, I am absolutely fecking petrified.

I know it's probably highly irrational, but after having a subarachnoid hemorrhage (anuerysm) I must say the last dozen or so pages haven't helped my fear. I know that the risk is miniscule and might not even be related to the vaccine, but the worry is still there.
If it's any help I will say that both the German and the UK haematology specialists are saying that the benefits outweigh the risks. In particular that there's no sign that these rare adverse reactions are more common in people with a history of thrombosis or aneurism.

The German report just emphasises the need for everyone, including doctors, to be alert to possible symptoms - like multiple bruising points and prolonged headaches.
 

jojojo

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Im sure its been explained somewhere but I seem to have missed it. Does anyone know how often we will have to take these vaccines? Yearly? Every 2 years or longer?
Cheers
Still unknown, as we don't really know enough about how quickly immunity wears off. Antibodies are declining markedly by about 6 months, but other bits of the immune system like T cells may still be ready to fight.

What is very likely though is that we'll see tweaked vaccines later this year, that are designed to target the worst of the new strains. At the moment it looks as if the SA variant is the one that they'll use as a target and that it should protect against the other common mutations as well. It's thought that would be used as a single shot booster for the already vaccinated. But that's all guesswork until the months pass, and the clinical trials get done.
 

Dumbstar

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Study says over 20% were over 65. Were any other age groups mentioned, particularly young teenagers - preferably females?
 

jojojo

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The big question now is can AZ rebuild trust in the vaccine. Which, in part at least, means can they get to the bottom of why Norway in particular has seen a cluster of severe adverse reactions. Have other incidents been missed in the UK and EU or is there some other factor involved.


ETA: @Wolverine - we must have both posted more or less simultaneously there, and then deleted simultaneously! I've restored one...
 

Stack

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Still unknown, as we don't really know enough about how quickly immunity wears off. Antibodies are declining markedly by about 6 months, but other bits of the immune system like T cells may still be ready to fight.

What is very likely though is that we'll see tweaked vaccines later this year, that are designed to target the worst of the new strains. At the moment it looks as if the SA variant is the one that they'll use as a target and that it should protect against the other common mutations as well. It's thought that would be used as a single shot booster for the already vaccinated. But that's all guesswork until the months pass, and the clinical trials get done.
Thanks for that. It will be interesting to see how the whole vaccine passport thing plays out over the next couple of years.
 

Kasper

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Interesting that the US trial had a four week interval which led to the 79%. Common right now is a 12 week interval, right? (At least friends of mine are getting it in a 12 week interval). Feels like there`s an abundance of different results with regarding to effiency and intervals at AZ - has the "half dose" approach led to anything?
 

BD

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Got booked in for a vaccine for this week. On one hand I'm happy to get it and I understand everyone has to get it at some stage, so once I get it when I can, then that's the main thing.

On the other hand, I'm 27 with no known health issues, so it feels a bit shitty that I'm here getting it while my parents back home are still waiting (and will be for a while it seems), as well as countless other people in less well off countries who are dying.

Is it a completely naive wish to have thought that a more global vaccination program could've been done? I guess so, but it would've been nice to see.
 

Solius

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Got booked in for a vaccine for this week. On one hand I'm happy to get it and I understand everyone has to get it at some stage, so once I get it when I can, then that's the main thing.

On the other hand, I'm 27 with no known health issues, so it feels a bit shitty that I'm here getting it while my parents back home are still waiting (and will be for a while it seems), as well as countless other people in less well off countries who are dying.

Is it a completely naive wish to have thought that a more global vaccination program could've been done? I guess so, but it would've been nice to see.
Did they call you?
 

Solius

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I keep hearing about people that have asthma getting it regardless of age, and also people who haven't had asthma for years getting the jab. My gf takes her inhaler pretty much every time we go on a walk atm but our GP says not to call to ask about when you'll get the vaccine.
 

BD

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Sounds efficient!
I was going to say something about the Swiss being efficient in everything they do (which is generally true), but their response to the whole pandemic has been quite...peculiar.

But yeah, an email arriving today saying my appointment is at 11am on Thursday and then my second dose is exactly 4 weeks later (same day, same time) is very Swiss.
 

groovyalbert

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I keep hearing about people that have asthma getting it regardless of age, and also people who haven't had asthma for years getting the jab. My gf takes her inhaler pretty much every time we go on a walk atm but our GP says not to call to ask about when you'll get the vaccine.
Yeah, I have a mate who was able to get his vaccine this way. I think it depends on they type of inhaler you were prescribed.
 

Pexbo

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I keep hearing about people that have asthma getting it regardless of age, and also people who haven't had asthma for years getting the jab. My gf takes her inhaler pretty much every time we go on a walk atm but our GP says not to call to ask about when you'll get the vaccine.
Good chance you’re with the same practice as me and they’re fecking useless.
 

Cal?

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Just had the Pfizer first dose a few hours ago, no issue whatsoever, not even any pain on the injection site. :D
 

Wolverine

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I keep hearing about people that have asthma getting it regardless of age, and also people who haven't had asthma for years getting the jab. My gf takes her inhaler pretty much every time we go on a walk atm but our GP says not to call to ask about when you'll get the vaccine.
So the current guidance for asthmatic patients is
  • If you were sent a shielding letter, you will be in priority group 4 - should already be vaccinated
  • If you have ever had an emergency hospital admission for asthma, or ever been prescribed three courses of steroid tablets (prednisolone) in a three-month period, you will fall into priority group 6 (i.e. the 16-64 year old with med conditions) - should have an invite for vaccination at the very least
  • If you do not fall into either of these groups and are under the age of 50, you will be vaccinated after the first nine priority groups.
Trouble is with inconsistencies in algorithms by NHS England and incorrect coding on records (largely out of control of GP practices) so there are many asthmatics who probably shouldn't strictly have had jabs who have had it, hence the confusion

If your girlfriend has severe asthma and falls into group 6 i'd advise speaking to practice manager of the practice or speak to the clinician within the practice that is clinical lead for covid vaccines and if that fails give NHS england a message/complaint
https://www.england.nhs.uk/contact-us/complaint/complaining-to-nhse/