Depends on a lot of factors. For example, style of play and the team the defender is playing for. Whether it’s a top team who’s inclined to play a proactive way like us, Bayern, Chelsea, Barcelona etc or even smaller clubs like Brighton who want to play out from the back, the CBs need to play through the lines along with defend, while the full backs need to basically act like wing backs. More difficult, I’m not sure, but there’s definitely more to do than lump the ball up and keep the shape, as it was two decades ago, which imo is a positive evolution.
If it’s a team like Burnley though, then it’s basically still the same. As aforementioned, keep the shape, full backs generally stay back, lump it up. For these teams who still play in this more basic way (no slight on them), then I don’t think being a defender there is harder in any way whatsoever.