This is amazing. Interesting ramifications for a mission to mars as well.
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Genes control to major TomSo he's a real space oddity?
Genes control to major Tom
I understood nothing of this post.Bad headline.
His gene expression changed in response to stress - this is the classic example of how we analyse networks in bacteria too (grow them, stress them, see how the gene expression changes, dive into the details of the changed genes). It is literally exactly what should have happened. The expression mostly returned to baseline when he came back home. What also changed was the epigenetic marks on the DNA, which are known to play a role in the regulation of gene expression - this is also expected stuff.
The use of the word "mutation" in the article seems to be misleading, nowhere else do they mention a change in DNA *sequence*.
The part about telomeres increasing length (which has implications of lifespan and cancer (both increase)), is what is true regarding the headline, but telomeres length does change even on earth, in response to stress. Stress was thought to shorten telomeres, but the correlation was weak. There is an interesting article showing a mechanism by which stress that causes DNA damage (like UV exposure) might lengthen telomeres as a side-effect of the DNA repair machinery involved in the response to DNA damage. This could have been happening to him in space. Still, it is interesting that they got back to normal length once he got back home, and I wouldn't know how to explain that.
I understood nothing of this post.
This post is amazing. Maybe my favorite post.Bad headline.
His gene expression changed in response to stress - this is the classic example of how we analyse networks in bacteria too (grow them, stress them, see how the gene expression changes, dive into the details of the changed genes). It is literally exactly what should have happened. The expression mostly returned to baseline when he came back home. What also changed was the epigenetic marks on the DNA, which are known to play a role in the regulation of gene expression - this is also expected stuff.
The use of the word "mutation" in the article seems to be misleading, nowhere else do they mention a change in DNA *sequence*.
The part about telomeres increasing length (which has implications of lifespan and cancer (both increase)), is what is true regarding the headline, but telomeres length does change even on earth, in response to stress. Stress was thought to shorten telomeres, but the correlation was weak. There is an interesting article showing a mechanism by which stress that causes DNA damage (like UV exposure) might lengthen telomeres as a side-effect of the DNA repair machinery involved in the response to DNA damage. This could have been happening to him in space. Still, it is interesting that they got back to normal length once he got back home, and I wouldn't know how to explain that.
*blushes*This post is amazing. Maybe my favorite post.
If i ever wonder about anything i will ask you. You are by far the smartest person i have ever seen.
Yes, the Café can be incredible like that at times.This post is amazing. Maybe my favorite post.
Is there a good popular science book about epigenetics?Bad headline.
His gene expression changed in response to stress - this is the classic example of how we analyse networks in bacteria too (grow them, stress them, see how the gene expression changes, dive into the details of the changed genes). It is literally exactly what should have happened. The expression mostly returned to baseline when he came back home. What also changed was the epigenetic marks on the DNA, which are known to play a role in the regulation of gene expression - this is also expected stuff.
The use of the word "mutation" in the article seems to be misleading, nowhere else do they mention a change in DNA *sequence*.
The part about telomeres increasing length (which has implications of lifespan and cancer (both increase)), is what is true regarding the headline, but telomeres length does change even on earth, in response to stress. Stress was thought to shorten telomeres, but the correlation was weak. There is an interesting article showing a mechanism by which stress that causes DNA damage (like UV exposure) might lengthen telomeres as a side-effect of the DNA repair machinery involved in the response to DNA damage. This could have been happening to him in space. Still, it is interesting that they got back to normal length once he got back home, and I wouldn't know how to explain that.
Innit. Was just about to say this.Bad headline.
His gene expression changed in response to stress - this is the classic example of how we analyse networks in bacteria too (grow them, stress them, see how the gene expression changes, dive into the details of the changed genes). It is literally exactly what should have happened. The expression mostly returned to baseline when he came back home. What also changed was the epigenetic marks on the DNA, which are known to play a role in the regulation of gene expression - this is also expected stuff.
The use of the word "mutation" in the article seems to be misleading, nowhere else do they mention a change in DNA *sequence*.
The part about telomeres increasing length (which has implications of lifespan and cancer (both increase)), is what is true regarding the headline, but telomeres length does change even on earth, in response to stress. Stress was thought to shorten telomeres, but the correlation was weak. There is an interesting article showing a mechanism by which stress that causes DNA damage (like UV exposure) might lengthen telomeres as a side-effect of the DNA repair machinery involved in the response to DNA damage. This could have been happening to him in space. Still, it is interesting that they got back to normal length once he got back home, and I wouldn't know how to explain that.
Innit. Was just about to say this.
Way to ruin my sensational headline with facts.Bad headline.
His gene expression changed in response to stress - this is the classic example of how we analyse networks in bacteria too (grow them, stress them, see how the gene expression changes, dive into the details of the changed genes). It is literally exactly what should have happened. The expression mostly returned to baseline when he came back home. What also changed was the epigenetic marks on the DNA, which are known to play a role in the regulation of gene expression - this is also expected stuff.
The use of the word "mutation" in the article seems to be misleading, nowhere else do they mention a change in DNA *sequence*.
The part about telomeres increasing length (which has implications of lifespan and cancer (both increase)), is what is true regarding the headline, but telomeres length does change even on earth, in response to stress. Stress was thought to shorten telomeres, but the correlation was weak. There is an interesting article showing a mechanism by which stress that causes DNA damage (like UV exposure) might lengthen telomeres as a side-effect of the DNA repair machinery involved in the response to DNA damage. This could have been happening to him in space. Still, it is interesting that they got back to normal length once he got back home, and I wouldn't know how to explain that.
Bump the post again at awards time, I say!*blushes*
Lol I just happen to be studying similar stuff, but thanks.
Take. A. Bow. Cheers!Bad headline.
His gene expression changed in response to stress - this is the classic example of how we analyse networks in bacteria too (grow them, stress them, see how the gene expression changes, dive into the details of the changed genes). It is literally exactly what should have happened. The expression mostly returned to baseline when he came back home. What also changed was the epigenetic marks on the DNA, which are known to play a role in the regulation of gene expression - this is also expected stuff.
The use of the word "mutation" in the article seems to be misleading, nowhere else do they mention a change in DNA *sequence*.
The part about telomeres increasing length (which has implications of lifespan and cancer (both increase)), is what is true regarding the headline, but telomeres length does change even on earth, in response to stress. Stress was thought to shorten telomeres, but the correlation was weak. There is an interesting article showing a mechanism by which stress that causes DNA damage (like UV exposure) might lengthen telomeres as a side-effect of the DNA repair machinery involved in the response to DNA damage. This could have been happening to him in space. Still, it is interesting that they got back to normal length once he got back home, and I wouldn't know how to explain that.