I think we'll play the same formation again, perhaps switching out Cavani for Rashford to give a bit more pace on the counter. You have to think that Atalanta will have more about them than Spurs, who were insipid, so we may get forced a little deeper at times than Spurs ever managed. Rashford's pace could help. Plus leaving out our young attackers (Rashford, Sancho, Greenwood) isn't really a long term option for us.
In terms of the result, I feel pretty sure we'll get at least a draw. I think we've parked the idea of playing football on the front foot for at least this week. Switching out an attacker for a defender is bound to tighten things up really, so I think we'll do that, and given the space they leave you in midfield, you have to feel that Bruno will be good to release a through ball or two for our attackers.