Got the first "ending" yesterday after 31 attempts, quite pleased with that. Even better, it was with the sword, which was the only weapon I hadn't cleared with, and I arrived at the final boss in pretty bad shape. Shitty build, down to my last death defiance and not even full health. So I pretty much got that one for free.
I guess it's time for some cautious first attempts at heat runs. My builds are still all over the place though, so it's going to be a struggle more often than not. Sometimes all the right gods just seem to fall into my lap and I've had a run where I finished the game with all death defiances intact and over half health left, but those are rare. Other times I just never get anything that works well together, despite running god keepsakes. I'm already not looking forward to extreme measures with a shitty build.