I replayed all three of them back to back maybe four or five years ago, with all DLC, and the alternate ending, and loved it. The ending to three is still a bit of a stinker but the great DLC like Citadel softens the blow quite a bit.
1 definitely has the best story arc but 2 is the best game, it had the perfect balance of great combat, set pieces and companions, even if the main story with the collectors was a bit pointless overall.
I'd fecking love a remaster of all three, hell, even just the first, would be incredible, because story aside it's held up really, really badly as a game compared to the other two. GIMME.