SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

Rado_N

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Did anyone see Jon Stewart’s appearance on Colbert the other night peddling the lab leak theory? I think he’s lost his mind.
 

jojojo

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Did anyone see Jon Stewart’s appearance on Colbert the other night peddling the lab leak theory? I think he’s lost his mind.
Hmmm, didn't see it, but I will say a lab leak isn't an impossible concept. I don't buy the idea of a lab manufactured virus or deliberate lab leak. But an accidental infection to a lab worker working on a live virus? Not impossible.

The idea that "something" odd happened at the Wuhan lab (or indeed that the Wuhan Lab had already seen the virus leap to a human host but without causing disease) before the official Case Zero date in Wuhan is backed up by some circumstantial evidence. The WHO delegation really didn't have enough access to give an answer the questions.
 

Rado_N

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Hmmm, didn't see it, but I will say a lab leak isn't an impossible concept. I don't buy the idea of a lab manufactured virus or deliberate lab leak. But an accidental infection to a lab worker working on a live virus? Not impossible.

The idea that "something" odd happened at the Wuhan lab (or indeed that the Wuhan Lab had already seen the virus leap to a human host but without causing disease) before the official Case Zero date in Wuhan is backed up by some circumstantial evidence. The WHO delegation really didn't have enough access to give an answer the questions.
I think it’s reasonable to say it should be looked into, which it is being from what I understand, it was more the manner in which he went about it.

I was waiting for him to say he was joking but he just seemed kinda unhinged. A quick Google suggests he’s taken some flack for it too.
 

Massive Spanner

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:lol:

I’m actually feeling pretty fatigued at the moment, definitely more than after the first jab. Hope it passes quickly.
Nice, can't wait to get my 2 doses so I can attach some fridge magnets to myself, it's gonna be all the style soon. Gonna put a CR7 magnet on my arse.
 

Rado_N

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Nice, can't wait to get my 2 doses so I can attach some fridge magnets to myself, it's gonna be all the style soon. Gonna put a CR7 magnet on my arse.
@SirAF

I did! It seemed like a "bit" to me and not sure if entirely serious
I thought that at first but he just kept at it.

What did you get? Moderna hit me and my wife hard on the second one
AZ, we were eligible early so got the first about 12 weeks ago before they changed the rules.
 

Wibble

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thanks - he seems more involved than you suggest but in any case it disproves your wild anti vax theory.

another article on the tech and his involvement.

https://science.sciencemag.org/content/247/4949/1465
So he was second author on a 1990 paper concerning RNA being injected into mouse muscle which resulted in protein expression?

Vaguely in the area but nothing directly to do with current mRNA vaccine development. I seriously doubt that any of the other 6 authors would claim any such thing.

As Pogue said the video itself contains utter nonsense (and I scrubbed through and the nonsense continued) and to me seems indistinguishable from conspiracy theory covidiot ramblings.

1:20: statement that the spike protein in the mRA+NA vaccine is cytotoxic and "very destructive" the "inventor" agrees with this and says he has alerted the FDA - not true
2:30 onwards: The state that the problem is that mRAN vaccines go "everywhere" and are responsible for a wide range of terrible sounding side effects - not true as mRNA vaccines don't seem to have very few severe side effects.
5:20 ish: Claim about spikes possibly cleaving due to insufficient animal testing - No evidence that there was a lack of testing or any evidence of harm occurring

After that he claims to have friends at the FDA how "know" about this stuff but are presumably ignoring it. All 3 agree that this isn't like "any other" vaccine. Not stated but presumably they are suggesting that the bad side effects that, seem only visible to them, is due to the vaccine being "different" which seems to be unsupportable nonsense. We then head off into loopy shit suggesting that the vaccines causes babies to be born with their head spilt in half and the information is being suppressed. They then start saying that even if 50% of what they say is right it "is alarming" and something should be done as "we are in danger" - argument after argument build on a false premise and other false arguments. Nor so much arguments built on a foundation of quicksand but rather a foundation of diarrhea.

Listening in more detail showed it to be far far worse than I first through. I also didn't ignore any argument they made so they made not a single supportable point.
 
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DFreshKing

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So he was second author on a 1990 paper concerning RNA being injected into mouse muscle which resulted in protein expression?

Vaguely in the area but nothing directly to do with current mRNA vaccine development. I seriously doubt that any of the other 6 authors would claim any such thing.

As Pogue said the video itself contains utter nonsense (and I scrubbed through and the nonsense continued) and to me seems indistinguishable from conspiracy theory covidiot ramblings.

1:20: statement that the spike protein in the mRA+NA vaccine is cytotoxic and "very destructive" the "inventor" agrees with this and says he has alerted the FDA - not true
2:30 onwards: The state that the problem is that mRAN vaccines go "everywhere" and are responsible for a wide range of terrible sounding side effects - not true as mRNA vaccines don't seem to have very few severe side effects.
5:20 ish: Claim about spikes possibly cleaving due to insufficient animal testing - No evidence that there was a lack of testing or any evidence of harm occurring

After that he claims to have friends at the FDA how "know" about this stuff but are presumably ignoring it. All 3 agree that this isn't like "any other" vaccine. Not stated but presumably they are suggesting that the bad side effects that, seem only visible to them, is due to the vaccine being "different" which seems to be unsupportable nonsense. We then head off into loopy shit suggesting that the vaccines causes babies to be born with their head spilt in half and the information is being suppressed. They then start saying that even if 50% of what they say is right it "is alarming" and something should be done as "we are in danger" - argument after argument build on a false premise and other false arguments. Nor so much arguments built on a foundation of quicksand but rather a foundation of diarrhea.

Listening in more detail showed it to be far far worse than I first through. I also didn't ignore any argument they made so they made not a single supportable point.
Ramblings of disagreements and ad hominem attack. Could you supply the data that shows the protein does not go around the body or is cytotoxic. im sorry but wibble of redcafe Saying not true isn't all that convincing. You discredit his achievments and virology background is yours greater? Is their data flawed? - that's what they are using not mearly saying something is true or not true. They have had the vaccine so calling them like anti vaxxers is plainly ridiculous. If you want me to take your response seriously try not to attack the messenger it's a weary trope. Data please - I find their data a bit worrying.
 

Wibble

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Ramblings of disagreements and ad hominem attack. Could you supply the data that shows the protein does not go around the body or is cytotoxic. im sorry but wibble of redcafe Saying not true isn't all that convincing. You discredit his achievments and virology background is yours greater? Is their data flawed? - that's what they are using not mearly saying something is true or not true. They have had the vaccine so calling them like anti vaxxers is plainly ridiculous. If you want me to take your response seriously try not to attack the messenger it's a weary trope. Data please - I find their data a bit worrying.
There is zero evidence of toxicity much less cytotoxicity. I'm not saying it but the evidence is.

https://www.politifact.com/factchec...n-covid-19-vaccines-spike-protein-toxic-or-c/

Why would you think a vaccine being distributed around the body was a problem anyway? The whole video is unsupported statements so it is ironic you ask for evidence.

And I'm not attacking you for being misled by such rubbish. I just find it sad that such rubbish leads people astray.
 
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DFreshKing

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There is zero evidence of toxicity much less cytotoxicity. I'm not saying it but the evidence is.

https://www.politifact.com/factchec...n-covid-19-vaccines-spike-protein-toxic-or-c/

Why would you think a vaccine being distributed around the body was a problem anyway?

And I'm not attacking you for being misled by such rubbish. I just find it sad that such rubbish leads people astray.
Thanks, I understand but I'm not led astray and I don't feel attacked. I'm looking at the data from the Japanese and these scientist interpretations and I am worried. I may well not need be but this is exactly why I posted to see if the data could be interpreted different or it didn't matter. Do you not think we track adverse events and do huge safety studies to look for possible issues just like this?

On the subject of the vaccine being distributed around the body that's not what they actually said it was the spike protein was distributed around the body which could be an issue especially as the vaccine makers said it wouldn't in their submissions - (according to the podcast). Thanks for the link hopefully that is true that seems to be crux of the argument - if its not toxic there should not be a problem.
 

berbatrick

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Rest of the article is just posturing (much like the bulk of the lab leak articles), but this is interesting:

The lab leak theory says the furin cleavage site, a tiny enzyme dangling from the virus, is key to understanding the novel coronavirus’s origin.

Goldstein agrees. But, he said, that cleavage site actually points toward the virus’s natural origin.

“You cannot, in a normal cell culture, maintain the furin cleavage site,” he told me. When the COVID-19 virus is replicated in a cell culture in a lab, he said, the furin cleavage tends to delete itself. A peer-reviewed paper, published in late April in Nature, noted that habit and identified seven other papers that found a similar deletion.

So if researchers were using traditional methods and their preferred cell lines to try to force the virus to replicate, mutate, and change, the furin cleavage site would likely disappear.

The gain-of-function proponents say this furin site is too well adapted for humans to be an accident. But Goldstein said the opposite is true. The cleavage site is imperfect, so odd, that it could have only been a freak of nature. “No virologist would use that cleavage site,” he said.

It is possible to replicate the virus in a lab while preserving the cleavage site, Goldstein added, but it would “require doing things differently than everyone does them.” And, crucially, it would require them choosing cell cultures that replicate the virus more slowly.

So the researchers would have had to make a series of inefficient and strange decisions to preserve a tiny, novel, odd enzyme. Indeed, the researchers at Imperial College London behind the April Nature article found that the addition of four amino acids in the virus’s spike protein “occurred during its emergence from an animal reservoir and created a suboptimal furin [cleavage site].” Another study published in January in Stem Cell Research demonstrated how these furin sites naturally evolve in many coronaviruses.
https://foreignpolicy.com/2021/06/15/lab-leak-theory-doesnt-hold-up-covid-china/
 

Pexbo

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Did anyone see Jon Stewart’s appearance on Colbert the other night peddling the lab leak theory? I think he’s lost his mind.
From a comedic point of view I could see what he was doing, from a logic point of view, he’s not wrong. I think the problem is that people really look up to him as a bit of a grounded, wise head with rational takes on things so it was disappointing to see him mouthing off like a Fox News commentator.
 

fergieisold

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Quite bizarre and poor interpretation from you. One of the guys on the panel is the literal inventor of the mRNA vaccine technology and holds the patent for which these vaccines have been created. Maybe dig a bit more? Two of them have also had the vaccine along with being the inventor of its tech so no not anti vax at all. A smaller digestible video that has a snippet of what they are getting at. They are worried about the data, not the same as anti vax.

Unless this is all one big hoax then I apologize unreservedly but I've seen nothing to suggest that. The shouty guy did get in the way quite a lot I do agree but he did come out and apologise and its pinned to the comments.

You should not make the same mistake of shouting down something like the lableak theory as it can costs lives.

 

Pogue Mahone

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It’s really fascinating how aggressively the Delta variant took off in the UK but doesn’t seem to be doing the same in Ireland.

Latest update.

Among the mass of presentations, pictures, and numbers that made up the briefings from the HSE and NPHET representatives on Thursday, there was one particularly positive slide.

It appeared about halfway through the presentation from Prof Philip Nolan in the Department of Health.

Displayed was a bar chart for how many cases of the Delta variant have been detected each week since it first appeared in Ireland in April.

Then known as the Indian variant, the chart showed cases growing weekly through April, reaching a peak of just below 50 cases one week in early May.

Crucially, it showed, cases have been falling since then.

It’s ten weeks since the first case of Delta was detected in Ireland. It is made up about 5% of cases that have been analysed for the variant recently.

By comparison, about 60% of cases in England were Delta ten weeks after the first detection in the country.
Does anyone know if this pattern is the same throughout Europe?

Can anyone think of a reason why we’re seeing a different pattern in different countries?
 

2cents

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It’s really fascinating how aggressively the Delta variant took off in the UK but doesn’t seem to be doing the same in Ireland.

Latest update.



Does anyone know if this pattern is the same throughout Europe?

Can anyone think of a reason why we’re seeing a different pattern in different countries?
Would it be primarily due to the huge population of South Asian descent in the UK? Not in terms of genetics or anything, but general back-and-forth connections.
 

groovyalbert

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Would it be primarily due to the huge population of South Asian descent in the UK? Not in terms of genetics or anything, but general back-and-forth connections.
That's what I would have thought, plus these were the communities vaccine programmes were most struggling to connect with.
 

Classical Mechanic

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It’s really fascinating how aggressively the Delta variant took off in the UK but doesn’t seem to be doing the same in Ireland.

Latest update.



Does anyone know if this pattern is the same throughout Europe?

Can anyone think of a reason why we’re seeing a different pattern in different countries?
UK has a significant Indian community that brought the variant back when visiting family. These communities tend towards multi-generational living. There was an article on the BBC that featured an Indian lad who said they were coming back through Turkey to avoid quarantine rules. The UK starting opening up a fair bit before Ireland which had one of the strictest lockdowns in Europe. In England at least a lot of people seem to think that Covid is over now and the number of people wearing masks is decreasing massively. The young population in the UK has been partying for a couple of months. That's my guess anyway.

https://www.bbc.co.uk/news/uk-56984057
 
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Pogue Mahone

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UK has a significant Indian community that brought the variant back when visiting family. These communities tend towards multi-generational living. There was an article on the BBC that featured an Indian lad who said they were coming back through Turkey to avoid quarantine rules. The UK starting opening up a fair bit before Ireland which had one of the strictest lockdowns in Europe. In England at least a lot of people seem to think that Covid is over now and the number of people wearing masks is decreasing massively. The young population in the UK has been partying for a couple of months. That's my guess anyway.

https://www.bbc.co.uk/news/uk-56984057
If what happened in the Uk is all about travellers from India and their immediate contacts that would be pretty encouraging. As this might mean the increased transmissibility is being overstated.

The young people in Ireland have been partying pretty hard over the last couple of months too. They haven’t been able to hang out inside pubs/clubs but have been socialising like crazy by other means. I’m not too clued in on Uk reopening dates though. When did you start allowing indoor pubs/clubs to open?
 

DFreshKing

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If what happened in the Uk is all about travellers from India and their immediate contacts that would be pretty encouraging. As this might mean the increased transmissibility is being overstated.

The young people in Ireland have been partying pretty hard over the last couple of months too. They haven’t been able to hang out inside pubs/clubs but have been socialising like crazy by other means. I’m not too clued in on Uk reopening dates though. When did you start allowing indoor pubs/clubs to open?
Pubs are back indoors - rule of six, track and trace etc... but clubs are still shut until July 19th at the earliest. outdoor rave season is upon again though so plenty of younglings out and about now.
 

Pogue Mahone

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Interesting graphic but this article does suggest the spike protein gets in the cells and is the reason for the risk of blood clot (which remember when it was first found was called fake news). Now they have a fix it has been accepted as a 'rare' risk.

https://www.ft.com/content/f76eb802-ec05-4461-9956-b250115d0577
Not by scientists. They paused the AZ rollout while countries were desperate to get vaccines into arms because of those clots. That’s not something that happens because of fake news.
 

Classical Mechanic

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If what happened in the Uk is all about travellers from India and their immediate contacts that would be pretty encouraging. As this might mean the increased transmissibility is being overstated.

The young people in Ireland have been partying pretty hard over the last couple of months too. They haven’t been able to hang out inside pubs/clubs but have been socialising like crazy by other means. I’m not too clued in on Uk reopening dates though. When did you start allowing indoor pubs/clubs to open?
The link below details reopening in the UK. BBC also reported that in the initial hotspots there was a low instance of WFH. The numbers in the initial hotspots are now starting to recede.

https://www.gov.uk/government/publi...ng-2021/covid-19-response-spring-2021-summary
 

Pogue Mahone

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Pubs are back indoors - rule of six, track and trace etc... but clubs are still shut until July 19th at the earliest. outdoor rave season is upon again though so plenty of younglings out and about now.
When did that happen? I’m wondering if the Delta took off beforehand (i.e. when restrictions same as Ireland is now).

Also super curious about what’s going on with that variant in the rest of Europe.

Anyone?
 

DFreshKing

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When did that happen? I’m wondering if the Delta took off beforehand (i.e. when restrictions same as Ireland is now).

Also super curious about what’s going on with that variant in the rest of Europe.

Anyone?
17th May for pubs indoors. A lot of the increase was already happening but I'm sure that didn't reduce contacts. Although reports are most incidence of infection are in the 5-12 and teens category while hospital admissions and deaths are in the older category with around 40% having 1 or 2 doses of the vaccine.
 

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Isn't it also the case that in the UK we know much better which variants are going around? I remember last year that Wales were doing more genomic sequencing in a week than France were doing in a year. Not sure how well the other countries have caught up now.
 

fergieisold

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Interesting graphic but this article does suggest the spike protein gets in the cells and is the reason for the risk of blood clot (which remember when it was first found was called fake news). Now they have a fix it has been accepted as a 'rare' risk.


https://www.ft.com/content/f76eb802-ec05-4461-9956-b250115d0577
Well with the mRNA vaccine I thought that was the point. The spike protein is made within the cell and it then sits on the outside (forgive my poor biology) before being neutralised by the immune system. It seems very small amounts of the spike protein make there way into the blood stream but these levels quickly fall to zero. The point being actual Covid infection will produce many times higher levels of these spike proteins...so in terms of the vaccine I just don't see what the mechanism here is to damage organs etc.
 

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When did that happen? I’m wondering if the Delta took off beforehand (i.e. when restrictions same as Ireland is now).

Also super curious about what’s going on with that variant in the rest of Europe.

Anyone?
About 1% of cases in Italy. There have been around 100 confirmed Delta variant cases in Italy to date, although numbers may be higher as far less sequencing is done here than in the UK.

We expect the quarantine requirement to be reimposed soon for travellers from the UK - the PM has already made some comments about it.