I think the 4-2-2-2 would be worth a go with our current personnel. Like what we played against Chelsea at home last year.
Remember City circa 11-14 or so, where they'd have two up top (Aguero,Tevez,Dzeko,Balotelli,Negredo,etc), use Silva and Nasri as inside playmakers, coming in from the wings to link up with Touré with one of Fernandinho/Barry sitting, and their FBs (Zabaleta,Sagna,Kolarov,Clichy) providing the width?
Shaw and Dalot/Valencia can provide the width. Herrera can sit next to Matic who can venture further forwards where, in my opinion, he's much more useful. Martial and Pogba can be the inside playmakers. Martial's good on the left and always ends up coming inside anyway, and Pogba on the right means he'd have less defensive responsibility and can still be the teams playmaker when in possession with him coming inside allowing Dalot to overlap him. Then the two up top with Alexis/Lukaku/Rashford. Or you could have Alexis as the left playmaker and Martial up top alongside someone.