I think playing Pogba in a 2 man midfield makes us defensively vulnerable. I wouldn't be worried if we had a strong and balanced attack that could outscore our opponents, but we don't have that. Against top 6 opposition I think it will be a mistake to be defensively vulnerable AND have an ineffective unbalanced attack.
What we should do is play Pogba as no.10 behind a balanced front 3 of Rashford, Martial and Greenwood, with Greenwood on the right of the 3.
Behind Pogba we should have McTominay and other as our 2 man midfield. I would go with Matic as he's the lesser of 3 evils. I don't think Fred or Pereira are defensively good enough at all.
Back 4 of Shaw - Maguire - Jones - Wan-Bissaka GK De Gea.
I'm one of the few that doesn't hate Jones and Smalling.
Martial
Rashford - Pogba - Greenwood
Matic - McTominay
Shaw - Maguire - Jones - Wan-Bissaka
De Gea
The main strength of this team is the BALANCED front 3 supported to our best player, Pogba. It is also defensively solid. I think the balance of the team is so important and we've ignored it for 6 seasons.