The way Ten Hag opens the middle, whatever way he lines up in a 4-2-3-1, we will be overrun. He has to compensate for the lack of pace, Casemiro's inexperience at the back, and Dalot's lack of positional ability. A back three is probably the best course of action. Personally I'd go with Casemiro, Maguire and McT with AWB covering for Cas at right fullback/wingback as he is the most inexperienced in the role, and Dalot bombing up the left hand side where McT (who has a better engine than Maguire) can operate. Midfield is tricky, but with Dalot operating as a wingback with cover behind him I think you can afford to play Mainoo at the pivot with Bruno next to Amad and Garnacho further up, who are both technically gifted players and good with the ball at their feet - especially against Championship opposition. Leave Rashford and Eriksen on the bench until later on when the opposition is tired and space is easier to find.
Of course, what we probably will end up doing is mad back and forth football which will tire our players more than theirs, but one can dream.