Not really, it depends on the striker for me. The one you want to put on the wing, and the one operating centrally. For example, I wouldn't like to place Lewandowski in any variation on the wing because he is best in and around the box, same as Van Basten/Muller.
Ronaldo however liked to come deeper for the ball, take it and attack you from there. And he preffered that left side, so as long you have a complimentary forward who is also great in linking the play, dropping deeper or has excellent playmaking instincts you should be more then fine. So, (just in theory of course) Ronaldo - Pele - Best should work great.