Interesting if true about Brandon. I can't see it not being a three at the back unless Shaw has picked up a knock or Wan-Bissaka is still missing. Williams is right-footed which I reckon most neutrals don't know, so there is a possibility that he is being preferred over Dalot at Right Back today as well. Even if the latter turns out to be true, it doesn't mean we automatically go to a different formation, as Bailly could be involved in a back three also.
Any of these could be the play:
de Gea
Lindelof Maguire Shaw
Wan-Bissaka McTominay Matic Fred Williams
Fernandes
Martial
de Gea
Williams Lindelof Maguire Shaw
Matic
McTominay Fred
Fernandes
Greenwood Martial
de Gea
Bailly Lindelof Maguire
Williams McTominay Matic Fred Shaw
Fernandes
Martial
I'm going to be a little surprised if all of Matic, McTominay, Fred and Bruno don't start regardless of how we set up. I don't think Ighalo will start this, so if we do go with two strikers I expect Greenwood to get the nod. It'll feel a bit negative if we don't play two forwards, but either way I fancy a bit more of a diamond to try and stifle City's superior midfield.
I'd take a draw right off, but going to be bold and say we'll win 3-1 despit having sub 35% of the ball!