Resident Evil's problem is that a lack of any sort of quality control over the years, along with a wild number of spin offs, has meant that there really isn't any sort of agreed central canon any more. It would be interesting to see a TV series that spent some more time exploring the backstory around some of the events in the mainline games, but the backstory doesn't make any sense, so its kind of impossible to do it.
Instead developers keep having to come up with new stuff that kind of ignores what's gone on before and comes up with new plots and settings that sometimes contradicts earlier games. That's just about ok in a computer game, where a sequel can be as much about game mechanics as plot, but it makes a film or TV series impossible. Best case scenario for this TV show is that its good in its own right, while having nothing to do with the plots of earlier games other than the other knowing nod or Easter egg.