This formation in theory is maybe good, but you have to play on the strengths of your team, not against. We can discuss about the reasons why we brought manager that we don't have players for (once again), but 4-2-2-2 won't ever work with these players.
For 4-2-2-2 to work you need to have top full backs capable to run all day long up and down, and we don't have those. You need to have those two players behind forwards that are good in both direction, and he is playing wingers there. Playing Greenwood and Sancho in those two positions is ridiculous. I would understand if he tried Bruno and VdB for example, or Bruno and Lingard, those two combinations at least would have some chance to do something with the ball. When you have wingers there, they will try to use wings, and block with FB's, while opening huge space in the middle. Also, you can't control midfield as space between McT/Fred or Matic and those two is huge, and we have problems even when we are closer.
I am not saying 4-2-2-2 is not good option, but not with our players.