The vaccines | AZ approved in UK - Pfizer/Moderna rollout underway

When will you take a covid vaccine?

  • As part of a covid trial

  • When it's approved/available for my age/risk group

  • 6 months after the bulk of my age/risk group

  • At least a year and I want to choose the brand

  • Only if I have to - for work or travel etc

  • Ten years +


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Pogue Mahone

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Good! I'd much rather have one of the more effective ones.
It’s weird being picky about vaccines but I will definitely feel a bit of a pang of disappointment when my time comes round if I’m offered the AZ/Oxford jab. Although hopefully there will be better data published between now and then. I’m literally bottom of the queue so plenty of time left for them to convince me it’s as good as the others.
 

Sylar

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i dunno what the plan is around the country but my nan is late 80s and lives miles from town but they came to her house to vaccinate her
Same for mine
They gave her the Oxford one as the pfizer one can't be transported as it needs to be at a certain temp (high?) Whilst Oxford doesn't
 

zing

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Is there a list of health conditions that mean that you cannot take the Oxford vaccine available somewhere please?
 

Wolverine

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Seen a bunch of anti-vaxxers at the vaccination centre today! Don't look very menacing when there's only about 5 of them and in snow-appropriate knitwear and mittens.
Annoyingly I've just realised how extremely online I am seeing as I was the only one who understood most the references and everybody's in awe of my explanation of "the great reset"
 

Grinner

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Doing an arm workout before you get your jab can make it more effective apparently.

Sounds like bollocks to me but any excuse for a superwank....
 

Phil

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Seen a bunch of anti-vaxxers at the vaccination centre today! Don't look very menacing when there's only about 5 of them and in snow-appropriate knitwear and mittens.
Annoyingly I've just realised how extremely online I am seeing as I was the only one who understood most the references and everybody's in awe of my explanation of "the great reset"
Anti vax outside a centre in the UK? Ffs.
 

jojojo

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You’d expect them to deploy community nurses to do it as they visit lots of old people anyway.
I think the other change that's expected as more AstraZeneca vaccine becomes available is that local pharmacies will do it. I suspect GPs or pharmacists will also start doing day sessions in venues like church halls etc in smaller places.

So far a lot of the rollout has been Pfizer vaccines. Where I live it's meant that they have been able to vaccinate a big proportion of mobile over 70s, but they haven't been able to do their housebound over 80s or the smaller carehomes. They're waiting for their next delivery of AZ to do those.
 

Badunk

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I'm getting the Pfizer one on Tuesday at the local hospital. Can get the Oxford one if I want but have to travel about 10 miles for it. Wanted the Pfizer one anyway.
 

Wolverine

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I'm getting the Pfizer one on Tuesday at the local hospital. Can get the Oxford one if I want but have to travel about 10 miles for it. Wanted the Pfizer one anyway.
That has been the case for quite a few people actually, a lot of the kids and grandkids on behalf of our elderly patients seen today rearranged appts today as adamant that want to get the Pfizer. Last week a few delays as adamant about wanting the AZ.

Currently being allocated at random from what I can tell, we just get shipments of one or the other and book patients in. It is a pretty complex issue I feel with numerous factors to consider - scientific, logistically, supply, efficacy. I got the pfizer but for me getting one as soon as possible was always the main thing, and would have got AZ if I could have earlier.

And news that Johnson and Johnson are about to drop their ENSEMBLE 1 and/or 2 trial data for the Janssen vaccine in a few weeks (multinational, high number of participants in covid-hit countries) for consideration of FDA approval I think it'll be an interesting dynamic to observe in the future about perception and preference with regards to the approved vaccines once we have infrastructure in place to give them out in the community en-masse.
 

Pogue Mahone

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That has been the case for quite a few people actually, a lot of the kids and grandkids on behalf of our elderly patients seen today rearranged appts today as adamant that want to get the Pfizer. Last week a few delays as adamant about wanting the AZ.

Currently being allocated at random from what I can tell, we just get shipments of one or the other and book patients in. It is a pretty complex issue I feel with numerous factors to consider - scientific, logistically, supply, efficacy. I got the pfizer but for me getting one as soon as possible was always the main thing, and would have got AZ if I could have earlier.

And news that Johnson and Johnson are about to drop their ENSEMBLE 1 and/or 2 trial data for the Janssen vaccine in a few weeks (multinational, high number of participants in covid-hit countries) for consideration of FDA approval I think it'll be an interesting dynamic to observe in the future about perception and preference with regards to the approved vaccines once we have infrastructure in place to give them out in the community en-masse.
Results from the CureVac mRNA vaccine Phase 2B/3 study expected beginning of March too. HERALD trial.
 

11101

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It’s weird being picky about vaccines but I will definitely feel a bit of a pang of disappointment when my time comes round if I’m offered the AZ/Oxford jab. Although hopefully there will be better data published between now and then. I’m literally bottom of the queue so plenty of time left for them to convince me it’s as good as the others.
I want the most effective but I'll take whatever comes first, assuming the US or EU approve the AZ vaccine.

I wonder if come the summer-ish when there are hundreds of millions of doses from Pfizer, Moderna, J&J and whoever else, we will see the AZ vaccine being quietly dropped and sent to developing countries instead. Other than the UK of course, where the Great British Vaccine will be injected from a union jack coloured needle to the sound of God Save the Queen.
 

Badunk

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I think it's the perception that the Oxford one isn't as good. There was the whole "Oh, we only gave one dose to some of the people by accident and it was still pretty effective but two doses is 95% effective". Whereas Pfizer has just been 95% and no ambiguity. Plus, it's held at - 70 degrees, so it feels like it's more 'premium' or something. I don't know. Obviously, I'd be happy with either and I don't think I'd have travelled to get the Pfizer one if it was further away, but it's just how I feel about them.
 

rcoobc

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I think it's the perception that the Oxford one isn't as good. There was the whole "Oh, we only gave one dose to some of the people by accident and it was still pretty effective but two doses is 95% effective". Whereas Pfizer has just been 95% and no ambiguity. Plus, it's held at - 70 degrees, so it feels like it's more 'premium' or something. I don't know. Obviously, I'd be happy with either and I don't think I'd have travelled to get the Pfizer one if it was further away, but it's just how I feel about them.
So, this is not correct

The Oxford–AstraZeneca COVID-19 vaccine (codenamed AZD1222) is a COVID-19 vaccine developed by Oxford University and AstraZeneca given by intramuscular injection, using as a vector the modified chimpanzee adenovirus ChAdOx1.[6][7][8][9] One dosing regimen showed 90% efficiency when a half-dose was followed by a full-dose after at least one month, based on mixed trials with no participants over 55 years old.[10] Another dosing regimen showed 62% efficiency when given as two full doses separated by at least one month.[10
https://en.m.wikipedia.org/wiki/Oxford–AstraZeneca_COVID-19_vaccine

The half dose-full dose regimen was an accident or "serendipity" using their CEOs words, but doesn't seem to have formed the basis of getting it authorised (not enough evidence). If you are given astrazeneca, you'll be getting two full doses

I hope this explains why plenty feel Oxford/astra isnt as good.
 

Pogue Mahone

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Thanks. Both my parents are on anticoagulants. I guess I need to consult with their doctors..
You should. The risk with anticoagulants is the possibility of a haematoma in their arm from the injection. Probably a risk worth taking considering the upside but their doctors will be able to advise. Will depend on what type/dose anticoagulants they’ll on and what they’ve been prescribed for.
 

zing

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You should. The risk with anticoagulants is the possibility of a haematoma in their arm from the injection. Probably a risk worth taking considering the upside but their doctors will be able to advise. Will depend on what type/dose anticoagulants they’ll on and what they’ve been prescribed for.
Thank you.
 

Wolverine

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Thanks. Both my parents are on anticoagulants. I guess I need to consult with their doctors..
There's no reason why they can't get the vaccine unless their recent INR is severely deranged (if on warfarin), the new anti-coagulants are fine too.
They get asked the question about anti-coagulants or blood thinners during consenting part pre-vaccination. Haematoma or bruising is an increased risk.

In practice it'll mean after vaccination firm pressure applied to the injection site in shoulder (with cotton gauze) without rubbing for at least two minutes.
Definitely have a discussion with primary care doctor if concerned but I've followed up a lot of the patients I gave the vaccination to on anti-coagulants in a subsequent flu vaccine clinic and there wasn't much of a issue by way of bruising etc thankfully.
 

zing

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There's no reason why they can't get the vaccine unless their recent INR is severely deranged (if on warfarin), the new anti-coagulants are fine too.
They get asked the question about anti-coagulants or blood thinners during consenting part pre-vaccination. Haematoma or bruising is an increased risk.

In practice it'll mean after vaccination firm pressure applied to the injection site in shoulder (with cotton gauze) without rubbing for at least two minutes.
Definitely have a discussion with primary care doctor if concerned but I've followed up a lot of the patients I gave the vaccination to on anti-coagulants in a subsequent flu vaccine clinic and there wasn't much of a issue by way of bruising etc thankfully.
My other half's Mother had her vaccine yesterday & she's on Warfarin.
Thank you - useful and helpful to hear.
 

11101

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I think it's the perception that the Oxford one isn't as good. There was the whole "Oh, we only gave one dose to some of the people by accident and it was still pretty effective but two doses is 95% effective". Whereas Pfizer has just been 95% and no ambiguity. Plus, it's held at - 70 degrees, so it feels like it's more 'premium' or something. I don't know. Obviously, I'd be happy with either and I don't think I'd have travelled to get the Pfizer one if it was further away, but it's just how I feel about them.
It's not only perception.

The US won't approve it until AZ have completed a new trial, with one of the FDA vaccine advisory panel members saying their data was odd and contained a serious error. The US trial for some reason is doing two full doses so likely won't be as effective even if it is approved.

Europe hasn't approved it either because 'the company first needs to demonstrate that all vaccines will be of high quality', and they haven't yet done that, according to the Deputy Head of the EMA.

Now you have the whole dose extension debacle and it's not hard to understand why some would prefer a different vaccine.
 

Wibble

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:lol: I get the sense you really enjoy posting bad news re the EU! Wouldn’t be too worried about this tbh. I remain to be convinced it’s a good vaccine. At the very least we need a better idea how it should be dosed. Hopefully have more data by the time we start injecting.
Its worst effectiveness data would have been good enough though. Obviously, we would all like to get a vaccine that is 95% effective but I'd take the Oxford one in a flash if it were the one on offer.

It might be the only one we have in AU. It looks like we were so late to the party ordering others that need importing that the Oxford one, which will be made here, may be the first cab off the rank and the only one for some time. We are only now thinking about ordering the Johnson and Johnson one - which could be good new if it is as effective as the rumors say - 100% and sterilising.
 

Pogue Mahone

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Its worst effectiveness data would have been good enough though. Obviously, we would all like to get a vaccine that is 95% effective but I'd take the Oxford one in a flash if it were the one on offer.

It might be the only one we have in AU. It looks like we were so late to the party ordering others that need importing that the Oxford one, which will be made here, may be the first cab off the rank and the only one for some time. We are only now thinking about ordering the Johnson and Johnson one - which could be good new if it is as effective as the rumors say - 100% and sterilising.
I’m sure it works. I just wouldn’t be keen on taking a vaccine that we don’t yet know what dose and what duration between doses works best. Not when there are other vaccines available where this is crystal clear.
 

Wibble

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Get vaccinated or kill Penna you selfish bastards
I’m sure it works. I just wouldn’t be keen on taking a vaccine that we don’t yet know what dose and what duration between doses works best. Not when there are other vaccines available where this is crystal clear.
Given a choice of course I'd go for the more effective one but I'd havexthe Oxford vaccine yesterday given the option.
 

Arruda

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Took my 2nd jab yesterday, the exact 21 days it was supposed to be.

Aching a bit all over the body, unlike the first shot. Glad I'm not working today, it would have been a tremendous sacrifice.
 

Crackers

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I’m sure it works. I just wouldn’t be keen on taking a vaccine that we don’t yet know what dose and what duration between doses works best. Not when there are other vaccines available where this is crystal clear.
If the AZ vaccine arrives in Ireland soon/few weeks (albeit in a shorter supply), how will it distributed throughout Ireland? More generally have they got a priority list of what vaccine goes where?

Moderna requires less intensive infrastructure than Pfizer, right? Basically how will AZ's vaccine play into our current distribution plans?