My choice:
De Gea
Rafael===Smalling===Vidic===Evra
Fletcher===Carrick===Cleverley
Januzaj===Welbeck===Lingard
Assuming all the injured players remain out then I'd like to try the above.
If Evans coming off against Sunderland writes him off as well then the defence starts to become a concern in terms of the number of injuries, so I think we have to go with that as we have no other options (other than Buttner for Evra).
Try three in central-midfield? Hope that Cleverley can provide some energy alongside Fletcher if Carrick plays deeper to support them? Again not many options in terms of the personnel, it's more a question of formation.
In terms of the attack then I think those three could be maybe the most fluid we could set-out. I want to give Jesse Lingard a proper chance from the start - he's earned it in my view and I'd hope the shitness of the team in recent times will take some of the pressure off him and allow him to play his game. Januzaj has been our best player recently, and then it's a choice between Welbeck or Hernandez where I think the former will provide a bit more flexibility to the attack. Valencia and Kagawa (sadly) haven't done enough in my view.
In reality I expect two in central-midfield, Valencia on the right, whomever is available on the left, Lingard in the stands and both Welbeck and Hernandez upfront from the start. Oh, and a poor performance naturally.