Phil Jones might be the one rested here with M.Keane, Evans, and Blackett making the back three.
Not sure who are the most likely wing backs, as Rafael doesn't seem to be fit, so on the right I think we'll still see Valencia or Young. Reece James should get the nod on the left.
As far as central midfield goes, we only have Fletcher and Cleverley unless LVG is going to play another youth player, while Kagawa will also support them. Another option is to only play one of Fletcher/Cleverley, then play both Kagawa and Januzaj ahead.
As for strikers, I'm hoping Wilson gets a chance, but cases can be made for van Persie, Welbeck, and Hernandez all needing the extra game.
De Gea
Valencia M.Keane Evans Blackett James
Cleverley
Januzaj Kagawa Welbeck
Van Persie
Could also see Jones in midfield if not Fletch?