saivet
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Pfizer and it must definitely be the vaccine because I'm still feeling so fecking tired.Which vaccine?
Pfizer and it must definitely be the vaccine because I'm still feeling so fecking tired.Which vaccine?
I had a fever and was tired after my second dose of moderna. Two days later i was better.Pfizer and it must definitely be the vaccine because I'm still feeling so fecking tired.
Yep, I was reading those numbers earlier. It's remarkable just how different they look once you break them down into the age bands.Must read thread as the Israel data has been misunderstood regarding vaccine efficacy.
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Sounds about right. I had mine on Sunday and was wiped Monday. Here we are on Wednesday and I'm still pretty tired.Pfizer and it must definitely be the vaccine because I'm still feeling so fecking tired.
I had a fever and was tired after my second dose of moderna. Two days later i was better.
No fever for me fortunately but just feeling pretty drained. Didn't experience any of this with the first dose.Sounds about right. I had mine on Sunday and was wiped Monday. Here we are on Wednesday and I'm still pretty tired.
That's what the thread addresses. The confounding variable is age.Yep, I was reading those numbers earlier. It's remarkable just how different they look once you break them down into the age bands.
I'm still not sure what is really being observed on the vaccine efficacy waning stuff either. Preparing to use boosters on some risk groups sounds reasonable, but I think there may be confiding factors we're missing in the Israeli data that's being cited.
It's this graph that I keep seeing quoted on the booster issue.That's what the thread addresses. The confounding variable is age.
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Effectively that's the ten years+ group. Anyone who's waiting for that long is planning on catching the SARS2 virus and hoping it doesn't hurt them or their friends, family, contacts.Can we add a ‘Not going to have the vaccine for any reason’ to the poll? Would be interesting to hear some view points from those who don’t want it or can’t have it.
I was Moderna and was 101.3F the next day. Lay in bed mostly.Which one did you get? The second dose of moderna knocked me out a bit. Maybe 25% of a fever. People I know saying the same thing about the moderna second dose.
I got out of bed but barely.I was Moderna and was 101.3F the next day. Lay in bed mostly.
Where?
For AZ? If so it was originally trailed with 8 to 12 week gaps between shots. Most places pushed towards 12 weeks to get as many people their first shot as soon as possible but some places like Australia, where AZ supply is fine, have now moved from 12 weeks to 4 weeks minimum to try to limit a serious outbreak of SARS-CoV-2 Delta.
Whoops. Jamaica. Trying to get as many vaccinated as possible partially.This made me laugh more than it should. Twice Ramshock asked where and ….
€2k if you use one and 3 years if you're selling them.Hopefully that risk is a massive fine and prison.
ContextWhoops. Jamaica. Trying to get as many vaccinated as possible partially.
Initially went well but not a major country so supplies delayed uptake. We're finally getting supplies in now to get to 50% or more by end of the year but there's not been enough dosages applied since end of July when supply was no longer a problem.
We're around 300k first and single doses but only around 140k fully vaxxed.
Population is around 3 million so way off the target we have which is 2 million by March and 1 million by October.
So we'll definitely be taking longer between doses. J & J is supposed to be at least half of that 1 million target though and that should be arriving by end of the month so we'll see what happens there.
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Most likely I won't take one for the time being as I already had COVID 5 months ago and still have antibodies. Probably next year, but will wait to see how each vaccine fares with the delta.Can we add a ‘Not going to have the vaccine for any reason’ to the poll? Would be interesting to hear some view points from those who don’t want it or can’t have it.
I looks like Australia is planning a third Delta tweaked shot of Modena or Pfiser for everyone in 2022.Yup - I was discussing this with @Wibble and expecting FDA to reccomend a booster shot for the entire general population.
Your immunity will almost certainly be better if you are vaccinated now and you can still get a Delta tweaked shot when they are available.Most likely I won't take one for the time being as I already had COVID 5 months ago and still have antibodies. Probably next year, but will wait to see how each vaccine fares with the delta.
There's no shortage of vaccines otherwise.
Great stuff. Almost as if vaccination works
This is really interesting because while there are variations in the mRNA sequence the amino acid sequence, based on this, is identical for the 2 vaccines. I wonder if this is suggesting that Moderna's carrier method is more effective than Pfizers? They are both using lipids, and from what I have read they use some in common, so the few differences must be key. Can't wait to see the follow up papers on this.
there must be a substantial difference in vectors (right word?) given the different storage temps (-80, -20)This is really interesting because while there are variations in the mRNA sequence the amino acid sequence, based on this, is identical for the 2 vaccines. I wonder if this is suggesting that Moderna's carrier method is more effective than Pfizers? They are both using lipids, and from what I have read they use some in common, so the few differences must be key. Can't wait to see the follow up papers on this.
Not sure. I found this website breaking down the carrier and transport media compositions and there are some differences but they are both using the same idea (cationic lipid nanoparticles). I am guessing that the Moderna lipids may be more stable at the "lower" temp, either due to the lipds themselves or modifications to the transport media.there must be a substantial difference in vectors (right word?) given the different storage temps (-80, -20)
Maybe it could be the does of vaccine given? The Moderna jab gives you 100 micrograms of vaccine compared to 30 micrograms with Phizer. There didn't appear to be much effect from that, but possibly it's showing its effect over time.This is really interesting because while there are variations in the mRNA sequence the amino acid sequence, based on this, is identical for the 2 vaccines. I wonder if this is suggesting that Moderna's carrier method is more effective than Pfizers? They are both using lipids, and from what I have read they use some in common, so the few differences must be key. Can't wait to see the follow up papers on this.
This is really interesting because while there are variations in the mRNA sequence the amino acid sequence, based on this, is identical for the 2 vaccines. I wonder if this is suggesting that Moderna's carrier method is more effective than Pfizers? They are both using lipids, and from what I have read they use some in common, so the few differences must be key. Can't wait to see the follow up papers on this.
there must be a substantial difference in vectors (right word?) given the different storage temps (-80, -20)
Not sure. I found this website breaking down the carrier and transport media compositions and there are some differences but they are both using the same idea (cationic lipid nanoparticles). I am guessing that the Moderna lipids may be more stable at the "lower" temp, either due to the lipds themselves or modifications to the transport media.
A Simple Breakdown of the Ingredients in the COVID Vaccines - COVID-19, Health Topics - Hackensack Meridian Health
Observational data is notoriously bad at identifying “real” differences between treatments. Loads of confounding variables. Especially in a scenario like this where one intervention was used much more often than the other (Pfizer doses vastly out-number Moderna throughout the EU)Maybe it could be the does of vaccine given? The Moderna jab gives you 100 micrograms of vaccine compared to 30 micrograms with Phizer. There didn't appear to be much effect from that, but possibly it's showing its effect over time.
It's because the cafe is full of old farts. The number is probably higher but one of the things about being old is your memory doesn't work as well. I only just remembered I had both doses by June but have only remembered to update the poll. I've moved it up to 54% now.Now 53.8. Only just realised there was a poll.
Guiltily as chargedIt's because the cafe is full of old farts. The number is probably higher but one of the things about being old is your memory doesn't work as well. I only just remembered I had both doses by June but have only remembered to update the poll. I've moved it up to 54% now.
No doubt this is the case, but everything I have ready suggests there is a real difference in the immunity provided by the 2 vaccines. There have been a few small scale studies looking at differences in IgG levels (GMT) and ID50's. Moderna does seem to produce higher GMT's, but it's hard to know if that is real without a large scale controlled study. That's what I meant by being excited about the follow up papers. Hopefully the lessons learned will help in the design of the second generation of mRNA vaccines,Observational data is notoriously bad at identifying “real” differences between treatments. Loads of confounding variables. Especially in a scenario like this where one intervention was used much more often than the other (Pfizer doses vastly out-number Moderna throughout the EU)
My only take home from this would be that both vaccines give excellent protection rather than wondering if one vaccine is better than the other.
The study I linked earlier also suggests similar.No doubt this is the case, but everything I have ready suggests there is a real difference in the immunity provided by the 2 vaccines. There have been a few small scale studies looking at differences in IgG levels (GMT) and ID50's. Moderna does seem to produce higher GMT's, but it's hard to know if that is real without a large scale controlled study. That's what I meant by being excited about the follow up papers. Hopefully the lessons learned will help in the design of the second generation of mRNA vaccines,