If we had a competent coaching staff, I would say that the priority is to stop their 4 players Capoue, Barejo, Albiol, Torres from playing deep and having their time to play like they wanted.
They just destroyed us in the first game, and we had no players in their zone, so a 4-1-4-1 would surely be efficient, but we don't have the players and confidence to do so.
Playing a 5-4-1 as we did recently ? Hope not.
So probably a 4-2-3-1 and no many changes from the Watford game.
---------------------------------------De Gea----------------------------------------
Wan Bissaka--------Maguire--------Lindelof------------------Telles
-----------------------Van de Beek--------Fred--------------------------------
Sancho----------------------------Bruno-------------------------Rashford
---------------------------------------Ronaldo-------------------------------------