Gary Neville was suggesting that they move to a back three with Zinchenko & Cancelo as wing backs (which might suit Zinchenko a bit more). That was prior to Stones getting injured but a back three of Otamendi, Fernandinho & Walker seems fine considering how they play.
They could then play Rodri & De Bruyne in midfield with a front three still intact. They're full of options to rotate in and out of midfield/attack as well. D. Silva, B. Silva, Rodri, Gundogan, De Bruyne, Sterling, Aguero, Jesus, Mahrez...ridiculous amount of talent there.