A very close friend of mine works as a nurse in one of Moscow clinics. They are now having hospitalizations of people who had their Sputnik shots. However, they are not allowed to record Covid in their health records. Thus, Sputnik seems to be as reliable as Chinese vaccines. 5/10 Would not take unless no other vaccine is on tne horizon in the next 12 months.
The vaccines | vaxxed boosted unvaxxed? New poll
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This thread is outstanding.
For the science types on here -- these findings seem consistent with the AZ findings.. can we expect the probabilities to converge for the two vaccines once more data is available? Is the underlying cause expected to be exactly the same?
This presentation seems to be more certain in their statement that the issue is more prevalent in women - something the EMA avoided saying. It does seem to be based on limited data.
Good stuff. Even more detailed than an AZ press release! Seems like they will continue with it, as they should.
And they indeed did recommend the continuation of usage for everyone over 18. Voting was: 10 in favor - 4 opposed - 1 abstention. The other main option was that it would be banned from women under 50. But they thought it would be confusing and that it would increase vaccine-hesitancy.
Probably too early to tell but common factors seem to be that adenovirus based vaccines seem to be affected but that it is very rare and affects younger women the most (although youngerv women who are nurses/doctors/health professionals were a large proportion of the initial vaccination program so it maybe mainly proportional). I also suspect that now we are looking for it the fatality rare will reduce.
Adenoviruses affecting platelets is thought to be the first step and an additive to AZ is thought to be the second factor that in combination trigger clots. That the J&J vaccine seems to have similar issues but doesn't have the same additive makes this hypothesis less certain to be the whole answer.
https://www.webmd.com/vaccines/covi...sts-find-how-astrazeneca-vaccine-causes-clots
Anyone has a detailed insight on what's going in the US with the restrictions regarding patents and is it hampering vaccine manufacturing in other parts of the world?
Also is it true that there are 40 mn AZ doses lying still in the US which they are never going to be using? If that's the case then they should export it to a country like India or the Covax initiative and let those who want to use them vaccinate their own people.
Also is it true that there are 40 mn AZ doses lying still in the US which they are never going to be using? If that's the case then they should export it to a country like India or the Covax initiative and let those who want to use them vaccinate their own people.
SII wanted to import raw materials for the Novavax vaccine, which they are planning to start manufacturing next month. US refused, so I don't know if they can make the vaccine. They said they don't need imports for the AZ vaccine, which is the only one they're making now.
And yes US is sitting on a few million AZ doses.
Next Monday morning i'm due for my 2nd dose of the Moderna vaccine.
Anyone who had it - what am i to expect please?
Anyone who had it - what am i to expect please?
I'm not sure if it's what you're thinking of, but there is a patent owned by the US government (the NIH to be precise) for a technique used to stabilise the spike proteins. Moderna, Pfizer, J&J and Novavax use it - AZ doesn't.
Is it hampering production? Not so far - and it's unlikely that it will be allowed to. There are various other patents owned by the individual companies but mostly the limit is manufacturing capacity/knowledge, and there's a lot of collaboration between companies underway.
The Defense Production Act is currently playing a bigger role with export bans on raw materials and manufacturing equipment as well as completed vaccines from the US. With the US approaching the "anyone can have a vaccine" point, they're expected to open the doors for exports soon. They do have AZ stockpiled and are likely to have surplus J&J and Novavax by Q3.
The worry would be if they immediately lock the doors again to produce autumn booster doses. Again, I'm hoping that they'll be confident enough about Moderna, Pfizer + an alternate (Novavax or J&J probably) to let all the stuff that those three companies don't need for US supply export freely again.
Nice visual risk contextualization for the AZ vaccine regarding different age groups and different infection rate scenarios from EMA:
Annexto Vaxzevria Art.5.3 -Visual risk contextualisation
Annexto Vaxzevria Art.5.3 -Visual risk contextualisation
I'm a bit confused by those graphics. Am I correct in interpreting them as comparing covid deaths to VITT cases (rather than VITT deaths)? And similarly for covid ICU admissions v VITT cases?
Anyone know if that's because we don't yet have a trusted survival rate stat or is it something else?
Yes that's the only thing I wondered as well and I think they didn't segment it for the reason you mentioned.
What is the reason for supplies running out for AZ then? Seems pretty hard to get the AZ jab anywhere here in Chennai. Half the week the centres are turning people away. Quite stop start
I think that’s it.
Hospitalisations is the best/fairest comparison as every VITT case will end up in hospital.
That's a good document and perfectly illustrates the reasoning behind restricting the vaccine to the over 60s.
SII are believed to producing around 60m doses per month. That's a lot, in one month they produce more than the total used by the UK and the EU so far (the UK plants produce about 8m doses/month in total for example)
In pandemic times though, and with India's current desperate need, it seems tiny. Increasing capacity relies on free flowing supply chains (which don't currently exist for some items) and increased supply of those raw materials/equipment. Increasing supply is very difficult. You can't just add a new supplier or order an existing company to make things faster. Plastic tubing for example might not sound specialised, but the absence of contaminants, resistance to leeching or degradation is not only different to achieve, it's tough to demonstrate.
It's agonising, but by any normal standards these companies have already produced better vaccines and ramped up far faster than seemed plausible a year ago.
I do have to ask. When these thing usually occur and that have human testing - the persons paid. I'm wondering why anyone would have got one early and is it right that they didn't get paid even? It seems people taking a big risk but for what reward?
To save their lives in the middle of a pandemic?
Take a look at UK deaths, how many more thousands would we have had without the vaccine rollout.
Personally I'm on a vaccine clinical trial. I was probably vaccinated in November. I was not paid to participate. The trials of that particular vaccine include around 60,000 people - and that numberstill wouldn't reveal the kind of problem we've seen on AZ since rollout. How many millions of people would you like to pay to see if any of them have adverse reactions?
EU going all in with Pfizer.
Looks like lessons have been learned from being slow off the mark securing initial supplies (also looks like they’re making a point to AZ re spotty supplies over last fee months)
I think even Pfizer Biontech must be surprised by how smoothly it's gone.
The other good news this week is that preliminary observations on taking the mRNA vaccines during pregnancy show that they look safe - for mother and baby. Still more data needed (9 months+ at least) but reassuring so far.
As standard, the advice had been that the vaccine was untested - so these are all women where the medical risk either outweighed any concern about the vaccine, or who didn't know they were pregnant, or became pregnant soon after getting the vaccine.
https://www.nejm.org/doi/full/10.1056/NEJMoa2104983
An article for the enthusiasts. A not too techie insight into the problems of increasing vaccine supply globally and the reason why it's not as easy as just sharing the recipe.
https://endpts.com/as-fears-mount-over-jj-and-astrazeneca-novavax-enters-a-shaky-spotlight/
https://endpts.com/as-fears-mount-over-jj-and-astrazeneca-novavax-enters-a-shaky-spotlight/
Still no side-effects apart from the sore arm, which is fine now.
I am hoping my bloodsugar levels is down to the vaccine, but i'm certain it's just me getting diabetes.
I am hoping my bloodsugar levels is down to the vaccine, but i'm certain it's just me getting diabetes.
2nd dose of Moderna vaccine tomorrow morning.
Anyone who had it can tell us the side-effects encountered please?
Anyone who had it can tell us the side-effects encountered please?
Thanks. Some part of the media in India seem to be suggestion that the US blocking the exports of this tech/raw materials is going to have a massive impact in the short term to India. But I see its another case of the Indian government messing up its vaccination policy. Novovax will anyway take a long time to start administering doses in India. What we need in the short term is to scale up the production of AZ/Covaxin and import as much as possible of the other leading vaccines from around the world.
The potential side effects will be the same as they potentially were for the first one. Whether you’ll experience them or not who knows, seems to be a toss up with all of them.
Novavax can start administering sooner than you think. It is being reviewed and expected to be approved soon in UK, I think.
Except for a hurting arm i had nothing else with the first one but i was told that the second can give you fever, chills headaches etc.
If you’re unlucky. No guarantee though so no point worrying about it
It can but the first one can do that too, seems a toss up, as @golden_blunder says nothing is guaranteed and I felt shocking after my first but was nothing a day in bed couldn’t fix
You will be fully cured of this horrible disease. So you may naturally start humming Y.NWA.
That's another disease so i leave it to you.
Getting my vaccine on Thursday, I'm under 30 so surely should be Pfizer even though it's reserve list
How’s your daughter doing?
She's better thanks. As the symptoms have been related to inflammation caused by the over active immune system I've been trying to get her to "eat" anti-inflammatories. So basically first fixing her gut with a good dose of fibre and cultures (Shreddies and Kefir for example). And supplementing with good quality omega 3 and vitamin D.
She's been able to go to school again in the last few months and even concentrate. Still gets headaches, fatigue, brain fog as well as other minor symptoms but more manageable now. No word from the long covid clinic that was supposed to contact us though. It's been 12 weeks.
Can anyone explain to me why the vaccines have to be manufactured in those tiny little bottles? Surely with such demand that can do it in big jugs or whatever.
@Dumbstar it's good to hear that she is improving. I remember you being one of the first posters to mention problems early last year so it's been an awful slog for your family. Best of luck.
@Dumbstar it's good to hear that she is improving. I remember you being one of the first posters to mention problems early last year so it's been an awful slog for your family. Best of luck.
I'd imagine it has something to do with the temperature the vaccine must be kept at. Too big of a vial and you'll have not used it all before it is too warm.
I'd guess it was more to do with being expensive to retool all of the machinery that is used to make that stuff. But yours sounds good too. But we are able to keep a pint of milk cold so you may be talking bollocks.
I double checked with the spousal unit. She said the Covid vaccine has a 6 hour use window once opened so it’s in small vials to prevent wastage.
We definitely need to apply milk technology to our vaccines.