I think they'll be plenty of rotation over the next two games, even though we'll a pretty strong side to come away with the win here. We definitely don't want a replay. I do get the feeling this is the competition José would most likely give up on if he had to pick one, but thanks to the St. Etienne result last night we can rest most of the first XI there.
Herrera is suspended for the Europa League second leg, so I assume he'll play against Blackburn (and then end up with 2-3 days off around the St. Etienne game). If Carrick and Rooney are ready, I'd like them to come in along with Shaw and probably Rojo. Not sure if Mkhitaryan will recover in time, so maybe he'll play in Europe instead.
de Gea
Valencia Smalling Rojo Shaw
Herrera Carrick
Lingard Rooney Rashford
Ibrahimovic
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Romero; Bailly, Young; Schweinsteiger, Fellaini; Mata; Martial
Thinking something like this, but there are question marks over quite a few players getting into the 18 (Shaw, Carrick, Rooney, Mkhitaryan). José may decide to stick with the same back four, for example. Changing only the goalkeeper, Pogba (as he is still nailed on to play in France), and a couple of the three behind Zlatan.