SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

Ekkie Thump

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Got turned around and asked to work from home. I really hope the supermarket shelves aren't raided out. My fridge is empty.
My last sortie (yesterday) revealed that there was plenty of everything except bog roll, pasta and hand-sanitiser. Fridge stuff is gonna be fine, beans'll be the next thing to go.
 

Utdstar01

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Feeling a bit under the weather. Have had a cold for the last 4 weeks. Woke up this morning heavier breathing than usual but inconsistent breathing patterns. Having to take deep breaths, almost like somebody is sitting on my chest. A bit of a cough coming on. Last few weeks when I've hit the gym I've noticed I've been getting out of breath quicker when doing cardio but I just put this down to half a stone I put on over Christmas so I'm not sure if this means anything.
 

Fully Fledged

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Do you think it will work with beer?
Well they recon that the alcohol in hand sanitizer kills the infection so it might work.
I’m thinking of trying whiskey instead stronger alcohol content after all.
If I give it a go tonight I might have to self isolate tomorrow though.
 

11101

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This is doing the rounds on medical whatsapp groups. Seems legit to me.



Full of jargon but you’ll get the jist of it. CM = cardiomyopathy, which I’m hearing about more and more. The virus seems to be directly cardiotoxic in the very unwell and that’s what kills them rather than ARDS.

Also confirms what we’re hearing from Italy. Being old/frail makes you more likely to end up in hospital but being young, fit, healthy is no guarantee that you won’t end up on a ventilator or dead.
It's interesting that certain drugs are being shown to have a positive effect. In Italy and China a small group of patients have been given a rheumatoid arthritis treatment with some success too.

It all gives me some hope we will find a treatment soon. Normal drug trial and approval timescales won't apply, especially once it kicks off in the US.
 

bosnian_red

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Indeed. Seasonal flu doesn't send 14% of people who get it to the hospital (and 8% to the ICU). It also doesn't kill otherwise healthy people in their 20s and 30s.
I mean it's important to note that there is a massive number of people who are just unreported. The people with mild cases (as would tend to be the majority) usually aren't going to confirm they have it or not. So the death rate and everything else is all the reported deaths as a percentage of the reported cases...which is likely well above the real death rate as the reported cases won't include loads of people who just have mild symptoms. Not like everyone with symptoms equal to a mild cold will go test themselves, that's impossible and would cripple the healthcare system even more (it's already happening to some extent where loads who have mild cases are going in out of panic).
 

11101

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Someone my mum knows is in Rome and allowed back so long as they self isolate. Seems kinda negligent as it’s unlikely them and their family will for a whole 2 weeks.
People come around to check on you.

I have a friend who lives in Milan and had a mini freak out on Monday and jumped on the last flight back to the UK. The flight was met by police on arrival who took everybody's details and told them to self isolate for 2 weeks. Of course he has been going out, going to the gym etc. since he's been back. I'd be half tempted to report him if i knew where he actually was.
 

Infra-red

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People come around to check on you.

I have a friend who lives in Milan and had a mini freak out on Monday and jumped on the last flight back to the UK. The flight was met by police on arrival who took everybody's details and told them to self isolate for 2 weeks. Of course he has been going out, going to the gym etc. since he's been back. I'd be half tempted to report him if i knew where he actually was.
This is the problem and why the reduced infection rate in China should offer us (in the West) no comfort at all. The draconian measures in place over there would never be tolerated or adhered to, in the West, as demonstrated by your idiotic friend.
 

montpelier

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For the UK at the maximum (hysterical) projected infection rate - 80% over 4 months. There should only be 1 in 4 people off work sick at any given time. Infrastructure ought not to completely breakdown by any means.

Certain areas and support for and around Old and sick people might be very difficult even at much lower rates of infection.
 

Bosws87

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Indeed. Seasonal flu doesn't send 14% of people who get it to the hospital (and 8% to the ICU). It also doesn't kill otherwise healthy people in their 20s and 30s.
But it does there is always anomalies to every virus disease you think 0 healthy people die of flu.
 

Dante

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I mean it's important to note that there is a massive number of people who are just unreported. The people with mild cases (as would tend to be the majority) usually aren't going to confirm they have it or not. So the death rate and everything else is all the reported deaths as a percentage of the reported cases...which is likely well above the real death rate as the reported cases won't include loads of people who just have mild symptoms. Not like everyone with symptoms equal to a mild cold will go test themselves, that's impossible and would cripple the healthcare system even more (it's already happening to some extent where loads who have mild cases are going in out of panic).
But all diseases are underreported. The best any statistician can do is to ensure they're using similar metrics to compare them.

So covid-19 might have a cfr of 2% with a bunch of unreported cases. But then flu will have a cfr of 0.2% and also have a bunch of unreported cases.

The only way to draw any reasonable equivalence is to assume that the data is going to be incomplete in every outbreak.

If we're talking about accurate numbers of infections versus deaths, I agree that the published figures are going to be wrong. But if all we're comparing is one disease to another in order to get an idea of severity, the only thing you can assume is that the data is flawed across the board.

As an indicative number, 2% is a helpful stat to work from.
 

11101

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Rumour has it that Italy is about to announce a total shutdown for 2 weeks. All shops and businesses barring pharmacies and supermarkets will be closed.

The next and presumably final stage, if it gets to that, is to clear the streets and assign one family member per household to be allowed out to visit the supermarket at an allocated time.
 

MarylandMUFan

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Rumour has it that Italy is about to announce a total shutdown for 2 weeks. All shops and businesses barring pharmacies and supermarkets will be closed.

The next and presumably final stage, if it gets to that, is to clear the streets and assign one family member per household to be allowed out to visit the supermarket at an allocated time.
Wow. Think about all of the life events being impacted here (like people that have a family member in hospice care and may not be able to visit them). This is really sad.
 

LilyWhiteSpur

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Rumour has it that Italy is about to announce a total shutdown for 2 weeks. All shops and businesses barring pharmacies and supermarkets will be closed.

The next and presumably final stage, if it gets to that, is to clear the streets and assign one family member per household to be allowed out to visit the supermarket at an allocated time.
The way the numbers are going Italy isn't going to be the only country. How we here in the UK are letting things like Cheltenham occur is beyond me.
 

Pogue Mahone

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It's interesting that certain drugs are being shown to have a positive effect. In Italy and China a small group of patients have been given a rheumatoid arthritis treatment with some success too.

It all gives me some hope we will find a treatment soon. Normal drug trial and approval timescales won't apply, especially once it kicks off in the US.
The thing is, it's impossible to know whether the drugs really are having an effect, or whether that improvement would have happend anyway, as their immune system starts to fight the illness. That's why we need randomised controlled trials to work out if drugs work. I could give every patient in ITU a mars bar, if half of them recovered does that mean that mars bars will help get 50% of patients out of ITU?
 

Pogue Mahone

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People come around to check on you.

I have a friend who lives in Milan and had a mini freak out on Monday and jumped on the last flight back to the UK. The flight was met by police on arrival who took everybody's details and told them to self isolate for 2 weeks. Of course he has been going out, going to the gym etc. since he's been back. I'd be half tempted to report him if i knew where he actually was.
Jesus. What a dickhead. Unfortunately, selfish twats like him are so prevalent it's inevitable that this will spread like wildfire.
 

11101

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The thing is, it's impossible to know whether the drugs really are having an effect, or whether that improvement would have happend anyway, as their immune system starts to fight the illness. That's why we need randomised controlled trials to work out if drugs work. I could give every patient in ITU a mars bar, if half of them recovered does that mean that mars bars will help get 50% of patients out of ITU?
Oh I am fully aware of biases etc, but in times like this humans have always been very resourceful. In WW2 things were being designed, built and tested in months instead of decades. I don't think it's a stretch to say this is the medical equivalent of that. There has almost certainly never before been such a concentration and collaboration of resources on a single topic.
 

Fully Fledged

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It's interesting that certain drugs are being shown to have a positive effect. In Italy and China a small group of patients have been given a rheumatoid arthritis treatment with some success too.

It all gives me some hope we will find a treatment soon. Normal drug trial and approval timescales won't apply, especially once it kicks off in the US.
Are the arthritis drugs steroid based?
 

Wolverine

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This is doing the rounds on medical whatsapp groups. Seems legit to me.



Full of jargon but you’ll get the jist of it. CM = cardiomyopathy, which I’m hearing about more and more. The virus seems to be directly cardiotoxic in the very unwell and that’s what kills them rather than ARDS.

Also confirms what we’re hearing from Italy. Being old/frail makes you more likely to end up in hospital but being young, fit, healthy is no guarantee that you won’t end up on a ventilator or dead.
Taking that quite seriously as obviously written by an intensivist who sounds like knows what talking about and especially worrying of a rapid myocarditis-like deterioration in the select patient he mentioned. But plural of anecdote not data, sampling, Berkson bias all have to be taken into consideration with the post.

Also interesting to note regarding Remdesivir, the LFT derangement being taken off as a contraindication and more widespread use should hopefully yield information regarding its use as an avenue for therapeutic intervention.
 

LilyWhiteSpur

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The thing is, it's impossible to know whether the drugs really are having an effect, or whether that improvement would have happend anyway, as their immune system starts to fight the illness. That's why we need randomised controlled trials to work out if drugs work. I could give every patient in ITU a mars bar, if half of them recovered does that mean that mars bars will help get 50% of patients out of ITU?
Yeah its important not to forget this is a Coronavirus we know absolutely nothing about up until 3 months ago.
 

Wolverine

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People come around to check on you.

I have a friend who lives in Milan and had a mini freak out on Monday and jumped on the last flight back to the UK. The flight was met by police on arrival who took everybody's details and told them to self isolate for 2 weeks. Of course he has been going out, going to the gym etc. since he's been back. I'd be half tempted to report him if i knew where he actually was.
Might be committing a legal offense
http://www.legislation.gov.uk/uksi/2020/129/regulation/15/made

15.—(1) A person (“P”) commits an offence if P—
(a)fails, without reasonable excuse, to comply with a restriction or requirement imposed under regulation 4(1), 5(1), 7(1) or 9(4) or (5);
(b)absconds, or attempts to abscond, from detention or isolation under regulation 4, 5 or 8.

(2) A person who provides false or misleading information intentionally or recklessly to any person carrying out a function under these Regulations commits an offence.

(3) A person who obstructs, without reasonable excuse, any person carrying out a function under these Regulations commits an offence.

(4) A responsible adult who fails without reasonable excuse to comply with regulation 5(4), 6(3) or 7(7) commits an offence.

(5) An offence specified in paragraphs (1), (2), (3) or (4) is punishable on summary conviction by a fine not exceeding level 3 on the standard scale.
 

worldgonemad

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Rumour has it that Italy is about to announce a total shutdown for 2 weeks. All shops and businesses barring pharmacies and supermarkets will be closed.

The next and presumably final stage, if it gets to that, is to clear the streets and assign one family member per household to be allowed out to visit the supermarket at an allocated time.
Source?
Please let this be not true. Absolute chaos if thats true.
 

11101

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Source?
Please let this be not true. Absolute chaos if thats true.
I have a friend who is a journalist in Milan.

It won't be a huge step on from what it is like now. Half the shops are already closed because there are no customers and i think by next week they all will be.