SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

711

Amadinho is the goat
Scout
Joined
Dec 10, 2007
Messages
24,396
Location
Don't sign old players and cast offs
Why doesn’t any lad not have his own set of clippers? I got a pair at Christmas costing 20 quid and they’ve given me a decent enough number 4 all over. Unless all you lads are looking for fancy designs and shit, self cut at home. Hell my wife even learned from YouTube how to cut her own hair and it looks good
Younger blokes will mostly go back to barbers, although not all, but the number of older fellas going will plummet. Why drive or walk to the barbers and sit waiting your turn to pay £8, or more in the south, when the missus can do it in five minutes flat? A lot of blokes have learned to do their own of course.
 

Pogue Mahone

Swiftie Fan Club President
Joined
Feb 22, 2006
Messages
134,483
Location
"like a man in silk pyjamas shooting pigeons
Two or three things.

- Firstly the government were furious that a newspaper broke news of the Lombardy lockdown ahead of time, so thousands of people fled to the other regions and took the virus with them. 2 days later the whole country was closed.

- It was always expected that it takes about a month for a new case to flush its way through an average household. Father has up to 14 days to show symptoms and infect grandma, who then might take another 14 days to show up before she infects son or brother who for whatever reason didn't get it from father at the beginning. It seems to be that it doesn't spread very effectively, but if you are exposed to it in the slightest it is extremely good at taking hold, if that makes sense.

- It has also been reducing more slowly in the South in areas that hadn't seen such devastating effects to begin with, and where people were not taking the rules as seriously.


Even in Wuhan where there was no question of how strong their lockdown was, it was 5 or 6 weeks before they started to see a consistent decline. Italy is just coming up to 6 weeks.
Yeah, that all makes sense.

Is that what you’re seeing geographically? Recent case numbers driven by regions which don’t have the sort of stringent lockdowns you mentioned above?
 

11101

Full Member
Joined
Aug 26, 2014
Messages
21,423
Yeah, that all makes sense.

Is that what you’re seeing geographically? Recent case numbers driven by regions which don’t have the sort of stringent lockdowns you mentioned above?
The whole country is locked down to the same extent in theory. The difference is in how seriously the residents take the restrictions. The North was hit hard and i think it's possible by now to say nobody is more than 2 degrees of separation from a death. Here within a few days everybody was following the rules. In the South even now there are stories of parties in apartment blocks and things like that.

Cases in the North have been declining since March but there are some regions in the South that haven't really seen any improvement at all, but it's orders of magnitude less. A bad day there is to report 100 cases, whereas a good day in Lombardy right now would be to go under 1,000.
 

adexkola

Doesn't understand sportswashing.
Joined
Mar 17, 2008
Messages
48,850
Location
The CL is a glorified FA Cup set to music
Supports
orderly disembarking on planes

Also, less than 2 weeks after announcing a ”work or home” order, my governor decides to do this...
I just drove by a golf course in CT and my mind remains blown that the parking lot was packed to the brim, with people on the green, golfing :wenger:
 

Sandikan

aka sex on the beach
Joined
Mar 14, 2011
Messages
53,752
Why doesn’t any lad not have his own set of clippers? I got a pair at Christmas costing 20 quid and they’ve given me a decent enough number 4 all over. Unless all you lads are looking for fancy designs and shit, self cut at home. Hell my wife even learned from YouTube how to cut her own hair and it looks good
I've never had anything fancy, but the idea of some shave your own head situation, even grade 4, which must be the least severe, is too much for me!
 

Arruda

Love is in the air, everywhere I look around
Joined
Apr 8, 2009
Messages
12,584
Location
Azores
Supports
Porto
Either the teams don't exist, weren't fit for purpose, or weren't listened to.
I cannot make a blanket statement for Europe, but that was certainly what happened in Portugal, and most likely the vast majority of Europe.

To me, doctors are to blame, they're the main culprits. Only a subset of them of course (mostly Public Health specialists, but not only), and a few other related categories of professionals.
 
Last edited:

Mr Pigeon

Illiterate Flying Rat
Scout
Joined
Mar 27, 2014
Messages
26,500
Location
bin
Sweden's numbers are shocking when you take in to account how few people live in it compared to the density of the UK. If anything it's evidence that they should've had a lock down, surely?
 

Smores

Full Member
Joined
May 18, 2011
Messages
25,653
Can't this feckers decide on a strategy?
To be fair (shudder) i don't think it'll be a change of strategy but they'll want to wrap the opening back up around a strategy they'd like to sell as a working one.

The UK could not have initially done what Sweden did as i don't think we'd have been as responsible, especially with bars open. Opening up from this a stricter position seems to me a lot more controlled as societal preparations have now been made.

Let's open up gradually and we'll be able to see if behaviour has adapted to not need full enforcement.
 

Pogue Mahone

Swiftie Fan Club President
Joined
Feb 22, 2006
Messages
134,483
Location
"like a man in silk pyjamas shooting pigeons
To be fair (shudder) i don't think it'll be a change of strategy but they'll want to wrap the opening back up around a strategy they'd like to sell as a working one.

The UK could not have initially done what Sweden did as i don't think we'd have been as responsible, especially with bars open. Opening up from this a stricter position seems to me a lot more controlled as societal preparations have now been made.

Let's open up gradually and we'll be able to see if behaviour has adapted to not need full enforcement.
Nobody can do what Sweden did without a much higher mortality (which is pretty high to begin with). Because nobody has 50% of their population living in single person accommodation.
 

Pogue Mahone

Swiftie Fan Club President
Joined
Feb 22, 2006
Messages
134,483
Location
"like a man in silk pyjamas shooting pigeons
The whole country is locked down to the same extent in theory. The difference is in how seriously the residents take the restrictions. The North was hit hard and i think it's possible by now to say nobody is more than 2 degrees of separation from a death. Here within a few days everybody was following the rules. In the South even now there are stories of parties in apartment blocks and things like that.

Cases in the North have been declining since March but there are some regions in the South that haven't really seen any improvement at all, but it's orders of magnitude less. A bad day there is to report 100 cases, whereas a good day in Lombardy right now would be to go under 1,000.
It’s the 1000 cases new a day in Lombardy that has me curious. In a region under total, very strict, lockdown. Could that realistically all still be spread within households? Or is something else going on?
 

Lj82

Full Member
Joined
Jun 12, 2016
Messages
1,060
Location
Singapore

golden_blunder

Site admin. Manchester United fan
Staff
Joined
Jun 1, 2000
Messages
120,963
Location
Dublin, Ireland
Comments closed on yt. More dislikes than likes.

I really thought the battle against racism and xenophobia was almost won in britain in the 90s and 00s. How wrong I was.
It’s crazy. The rise of Trump and the Brexit crew has enabled them to crawl out from under their rocks.
 

Mr Pigeon

Illiterate Flying Rat
Scout
Joined
Mar 27, 2014
Messages
26,500
Location
bin
'THERE'S NO PANDEMIC': People across the U.S., many of whom are vocal Trump supporters, are protesting stay-at-home orders.
COVID-19 has killed more than 37,000 people in America within the last 7 weeks.
Should be viewable here if below facebook link doesnt work: https://video-amt2-1.xx.fbcdn.net/v...=2beed8f0e93e87fdcd4afa82cea80fa8&oe=5EC0CFB2

"Let us back into the tarantula enclosure!" Demand peasants covered in tarantula luring jam.

"We must give the people what they want" says the man who sells tickets to the 'Watch peasants being eaten by horny tarantulas' show.
 

Dr. Dwayne

Self proclaimed tagline king.
Joined
May 9, 2006
Messages
97,914
Location
Nearer my Cas, to thee
Thanks Wibbs. I'm not inclined to believe this is man made but are you able to help me better understand his argument?

I don't find his first point about Yunnan compelling, maybe I'm misunderstanding it or it's worded badly but viruses and animals, especially ones that fly aren't known for their respect of political geography. If it's due to things like different ecosystems between the provinces I'd understand but these two places aren't that far away from each other.

The second point I'm just not knowledgeable enough. 20 - 50 years sounds like a long timeline but couldn't this be accelerated in a lab setting? How many generations of evolution does this represent for a coronavirus (that might be a better quantification for me)?
 

Hound Dog

Full Member
Joined
Mar 10, 2011
Messages
3,220
Location
Belgrade, Serbia
Supports
Whoever I bet on
Comments closed on yt. More dislikes than likes.

I really thought the battle against racism and xenophobia was almost won in britain in the 90s and 00s. How wrong I was.
That means nothing (comments, like to dislike ratio).

All you need to have to soil a video in that way is an interested party with a sufficient number of time/access to companies that will spam downvote a video.

For what its worth, the majority of children's videos on yt have a negative like to dislike rate and didabled comments.
 

Wibble

In Gadus Speramus
Staff
Joined
Jun 15, 2000
Messages
89,581
Location
Centreback
Thanks Wibbs. I'm not inclined to believe this is man made but are you able to help me better understand his argument?

I don't find his first point about Yunnan compelling, maybe I'm misunderstanding it or it's worded badly but viruses and animals, especially ones that fly aren't known for their respect of political geography. If it's due to things like different ecosystems between the provinces I'd understand but these two places aren't that far away from each other.

The second point I'm just not knowledgeable enough. 20 - 50 years sounds like a long timeline but couldn't this be accelerated in a lab setting? How many generations of evolution does this represent for a coronavirus (that might be a better quantification for me)?
I'd have to read it again but I think the point is that the virus in the lab can't be the source of Covid-19 because SARS-Cov-2 has taken 20-50 years of evolution to be in its current form. The virus held in the lab is the original virus RaTG13 so it can't have been an accidental release. The conspiracy theory that the lab were genetically engineering the virus also doesn't hold water as you couldn't possibly replicate 20-50 years of gradual evolution in a lab - it would look very different if engineered. Not that there is anyone not wearing (or listening to someone who is wearing) a tin foil hat who thinks this is what happened.

It is virtually certain that RaTG13 or a closely related virus passed from bats to another host and that the virus then jumped to humans from that host. Some evolution of the virus could have occurred in bats that were isolated from the original bat population that still has RaTG13 and then presumably further evolution occurred once the intermediate host was infected, but we will need to find the intermediate host to know this. Pangolins are the best guess at the moment but we just don't know what the intermediate host is yet. The chances are that we will eventually find an animal with a viruses very close to SARS-CoV-2.
 
Last edited:

sammsky1

Pochettino's #1 fan
Joined
Feb 10, 2008
Messages
32,841
Location
London
Cheers but it's saying that file/link has been removed. Still interested to read it if you have another source.
Link also here : https://mega.nz/file/rxs3CaJJ#8wth6thR2bmsu9HwOdAz82F4Z6n8l2d3hyG-fAKJBwE

Minutes of New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) 21 Feb: Corona threat "moderate"
minute 2.4 on page 5:

PH asked the committee if anyone thought that the PHE risk assessment should change. No objections were raised however after the meeting, JE emailed to say that he was online but for some technical reason could not be heard. JE believes that the risk to the UK population (in the PHE risk assessment) should be high, as there is evidence of ongoing transmission in Korea, Japan and Singapore, as well as in China.
 

RK

Full Member
Joined
May 23, 2008
Messages
16,106
Location
Attacking Midfield
Link also here : https://mega.nz/file/rxs3CaJJ#8wth6thR2bmsu9HwOdAz82F4Z6n8l2d3hyG-fAKJBwE

Minutes of New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) 21 Feb: Corona threat "moderate"
minute 2.4 on page 5:

PH asked the committee if anyone thought that the PHE risk assessment should change. No objections were raised however after the meeting, JE emailed to say that he was online but for some technical reason could not be heard. JE believes that the risk to the UK population (in the PHE risk assessment) should be high, as there is evidence of ongoing transmission in Korea, Japan and Singapore, as well as in China.
Cheers. Reading the minutes it seems like a failing of the risk level scale. NERVTAG's analysis of the situation looks relatively accurate, but

"Some members commented that there may be sustained transmission outside of Mainland China. Others commented that there is plenty of scope for escalation in the UK and this would be an argument to keep the assessment as moderate rather than high at this time."

The current level is "high" which suggests they only had one more card to play at the time (moderate to high). My interpretation is that they believed moving to high at the point would stymie them for further escalation, rather than it being an unfair reflection. It's frustrating that this single and low-precision recommendation seems to have trumped all of the underlying information. I'm sure it was being communicated, but not driven home to laymen.
 
Last edited:

MrPooni

New Member
Joined
Feb 10, 2012
Messages
2,423
Comments closed on yt. More dislikes than likes.

I really thought the battle against racism and xenophobia was almost won in britain in the 90s and 00s. How wrong I was.
To be fair, plenty of ethnic minorities spent the 90's and 00's screaming about how racism was alive and well but nobody believed us. It's only through the connectivity of the internet that we've been afforded the opportunity to collate and present evidence. Basically these sentiments were always there, the internet has just turned the volume up for both sides.
 

RedDevil@84

Full Member
Joined
Jun 5, 2014
Messages
21,800
Location
USA
'THERE'S NO PANDEMIC': People across the U.S., many of whom are vocal Trump supporters, are protesting stay-at-home orders.
COVID-19 has killed more than 37,000 people in America within the last 7 weeks.
Should be viewable here if below facebook link doesnt work: https://video-amt2-1.xx.fbcdn.net/v...=2beed8f0e93e87fdcd4afa82cea80fa8&oe=5EC0CFB2

Why don't they drive to DC and ask their Lord Leader to set them all free from the clutches of this evil State Governors. And they also can shake the hands of the Lord Leader to prove to the world that this is all a hoax.
 

berbatrick

Renaissance Man
Scout
Joined
Oct 22, 2010
Messages
21,920
@Dwazza Gunnar Solskjær
A small caveat is that I work with bacteria not viruses, but I think the same principles apply.

The way we do genetic changes is to target a particuar region of the genome and replace it. This could be an entire gene or a single letter at one position. Natural selection does not work like that.

During normal propogation of any species, there are random changes at random positions throughout the genome. Most of them don't stick - some are harmful, others have no fitness effect but simply disappear during random sampling to form the next generation. For this, imagine if a virus with some mutations that have no effect on its activity infected someone living totally alone. After that person fully recovers or dies that strain of the virus never gets a chance to spread, and that particular mutational strain vanishes. The same vanishing can happen for many many reasons.
Some of the mutations do stick - again, due to random sampling to form the next generation (say, a particular strain happens to infect a super-spreader), these become widespread. The rarest of mutations involve those that do impact the function of the virus in a positive way. This beneficial mutation at that same spot coud possibly be generated artificially in a lab studying the virus.

But because in natural evolution there are mutations everywhere compared to what you started with, this final extra-virulent virus will not resemble a lab strain, which will have only the mutation under study. In fact, if we study a particular mutation and accidentally create more mutations elsewhere, the study becomes invalid since we can't say for sure which mutation is doing what.

Because we know the background rate of mutations per generation and we know roughly how many generations per year, we have a rough estimate of how much the total number of mutations should be. That's how that professor was able to give an estimate of 50 years.


I hope this makes sense!
 
Last edited: