The main issue about Santos is in midfield. Without any creativity or mobility, Renato is already 38 and Vecchio was never known for his agility (el Gordo). In a 433 formation, a non-creative midfield is harmless; Santos was totally dominated by Real Garcilaso. The stubbornness from coach is another issue, some young prospects like Rodrygo, Yuri Alberto, Diogo Vitor and Gustavo Henrique (not so young) deserves opportunities in first team, but Jair Ventura keep saying that they “are too young” and the opportunity will come.
About Vasco, the weakest Brazilian team for me, but very strong at home, for me it’s likely they will win against Universidad. But, particularly, it seems very unlikely that they pass the group stage (Racing and Cruzeiro far better, imo), so the fight will be against Universidad to qualify to Sul Americana.