Other than Pepe I'm not sure i'd call any of those competent, and he hasn't played in midfield for about 10 years.
I'd actually say Pepe is the worst of the lot at playing cdm, it was just peak El Clasico bastardery on display with Mourinho being desperate to stop rampant Barcelona.
Regarding VNL I'm not sure he could do the job. But he is akin to Marquinhos so it could perhaps work out but I still can't see it happening. Then again never would I have imagined seeing Lahm at cdm, Schweinsteiger at cdm, Ze Roberto at cdm or Kimmich at cb but it happened.
Someone like Ivan Córdoba or Lucas Hernández - shorter tenacious CB's that are good man markers - might have an easier time to transition and do a good job of harrying the opposition as cdm.
Some CB's on the bigger end - van Buyten or Harry Mcguire - could probably become decent strikers for some teams in the lower divisions/lower table (or in Dion Dublins case all the way in premiership). It's about skill sets.