I don't know if any manager has gone from women's football to men's football and actually done well or not but from hearing Mark Sampson speaking years ago when he was in charge of and doing brilliantly with the England women's team, I thought he sounded like a really soft character and would struggle with the egos in men's football but would probably make a good youth team manager.
Phil Neville comes across as being exactly the same, he talks a good game because he learnt a lot from Sir Alex but it's knowing how to get your players going and turning the words into results.
I think most experienced footballers will find it hard to respect a manager who has got a job simply because he's a friend of the owners or because he used to play for Manchester United, it's a disastrous route to take in football, I remember when people used to say M Arteta would be a fantastic manager just because he's worked alongside P Gaurdiola and before that it was P Viera, T Henry, G Neville, R Keane, R Giggs and P Scholes will be brilliant managers and that didn't happen.
J Klopp started in the Germany's 2nd tier, P Gaurdiola started at Barcelona B, A Ferguson started at smaller clubs in Scotland, I remember Giggs being linked with so many jobs and not taking any of them, if players aren't prepared to take a job in a lower league because they think they are over qualified for it - they don't deserve the chance. (Barcelona B are basically a reserve team who play in a professional league so the opponents are of decent standard.)
We will see how it works out for Phil, I hope he can turn it around but I just can't see it.