Double vaxxed - I feel rough as shit but I’m sure I’ll be fine. Thanks man!Oh man, you had your vaccines right? Hopefully shouldn’t be too bad. Stay home and rest up buddy.
Double vaxxed - I feel rough as shit but I’m sure I’ll be fine. Thanks man!Oh man, you had your vaccines right? Hopefully shouldn’t be too bad. Stay home and rest up buddy.
That’s a real shame buddy. Very sorry to hear that.Been a real crappy week with regards to covid.
Have two friends. One had the AZ a while back and has been in hospital with suspected stroke. Months since he had the AZ. Don't know if linked. He is in early 40's. Being investigated for blood clots etc.
Another friend early 30's hospitalized due to covid. Seemed to be pulling through now in coma and critical. Don't think will pull through. Absolutely brilliant lad. Very fit and active. No underlying conditions.
Sorry to hear this - had the second lad been vaccinated? This is what’s so scary, you just dont know how bad its going to hit you.Been a real crappy week with regards to covid.
Have two friends. One had the AZ a while back and has been in hospital with suspected stroke. Months since he had the AZ. Don't know if linked. He is in early 40's. Being investigated for blood clots etc.
Another friend early 30's hospitalized due to covid. Seemed to be pulling through now in coma and critical. Don't think will pull through. Absolutely brilliant lad. Very fit and active. No underlying conditions.
Not 100% sure if he was vaccinated. Early thirties with no underlying conditions so not sure if the timetable for vaccines had caught him in time.Sorry to hear this - had the second lad been vaccinated? This is what’s so scary, you just dont know how bad its going to hit you.
Ever so slightly relieved to get a negative PCR test result through this morning having been pinged on Sunday.
Reassuring that you are virtually certain of avoiding serious disease. Good luck.Double vaxxed - I feel rough as shit but I’m sure I’ll be fine. Thanks man!
Yep, the idea of recommending boosters this early bothers me. If we can find some way of determining who needs a third dose, to get optimum impact from the vaccine - which seems to be the case with organ transplant patients and some others on immune-suppressants, for example - then great. If it's chasing the dream of herd immunity via infection prevention I don't see it.
I think that's been a common theme. People have seen the pandemic at different times. My family/friends were hit in the March 2020 wave - 4 people I knew died. In terms of my local area it was the winter 2020 peak that I saw kill a neighbour and hospitalise others before the vax reached their age group. Since the Delta wave started I've seen other family members catch covid (vaxxed 40-something parents/unvaxxed teens) but fortunately with no lasting damage.Strange thing is it's only in the last few months where people close to me have had the virus and I've known locals who have died from it. In the first year and half or so I saw the figures but didn't really know anyone getting or certainly dying from it. Now all of a sudden have known many who are close friends and family. Would say in the last 7 months or so.
It's strange because although it's still here, we seem to have the vaccine roll out going well and figures are not as bad as they were say a year ago. Certainly locally.
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Is the pneumonia connected to Covid?Of the 30 covid patients in my hospital, 2 are vaccinated, one is fine barely on any O2. Other guy is intubated, sicker but I think that's due to bacterial pneumonia.
Yep.Is the pneumonia connected to Covid?
Sorry I am clueless
The Venn diagram has them in the same circle as people who think Bruno wasn't fouled.Who are the ten years plus voters?
I think less than 10% of people who voted regulary check this thread so I doubt this poll is reflective of the current vaccination quota on the caf, even with the adapted thread title. Re-doing the whole poll would probably give a more accurate picture.Surely some of the 309 'When it's approved for my age group' posters have had theirs now. Change your votes, people.
Is the pneumonia connected to Covid?
Sorry I am clueless
No. Completely different. I cannot say for sure but it's my opinion that the bacterial pneumonia is the bigger issue rather than covid19.Yep.
Seeing as how we have an effective vaccine for COVID I would agree. I spent a decade studying Streptococcus pneumoniae and we were concerned about seroswitching back then. The pneumoccal vaccines are serotype specific and we were seeing continued infections, especially in children, but they were just different serotypes.No. Completely different. I cannot say for sure but it's my opinion that the bacterial pneumonia is the bigger issue rather than covid19.
This abstract refers to the following article with further details and references: https://www.scientificamerican.com/...igns-of-harming-fertility-or-sexual-function/. Its title and subtitle are this:Nature Briefiing said:Vaccines don’t affect fertility
There is no evidence that COVID-19 vaccines affect any aspect of reproduction or sexual functioning. Four experts in reproductive and sexual biology look at the facts about vaccines and pregnancy, menstruation and sperm and erectile function.
In case anyone still woried about this aspect.COVID Vaccines Show No Signs of Harming Fertility or Sexual Function
The novel coronavirus, in contrast, can disrupt both things in unvaccinated men and women
They should check marriage nextin case it's not been mentioned yet, here's a quote from today's Nature Briefing:
This abstract refers to the following article with further details and references: https://www.scientificamerican.com/...igns-of-harming-fertility-or-sexual-function/. Its title and subtitle are this:
In case anyone still woried about this aspect.
They should check marriage next
Worth bearing in mind that this isn’t because the virus is suddenly much more dangerous to young people. It’s because the older generations are much better protected with vaccines. Without vaccines you’d have at least 10 elderly admissions for each one of those youngsters.I’ve been working on ICU this week and we have 11 patients all of whom have COVID. The youngest 19 the eldest 70. The common denominator is that none have had the vaccine. 4 of them on end of life care. We have seen a huge rise in pregnant women with COVID as well- 3 of which are on ICU, 2 after delivery and 1 is going into theatre tomorrow. All on ICU for COVID reasons. It seems this disease is affecting the younger much more severe than when it first reared it’s head.
Surely the proportion of cases due to Delta has increased massively between the first one or two months after vaccination and five to six months? It’s not like the vaccines have been out all that long. So most people hitting six months post jab are getting infected at a time when they’re catching Delta. While most of the earlier, much higher, efficacy stats were generated when alpha was the only show in town.Meanwhile, data from the UK-based Zoe Covid Study app, where users can log whether they have been vaccinated, Covid test results and symptoms, has suggested protection against infection after two shots of the Pfizer/BioNTech jab decreased from 88% at one month to 74% at five to six months, while protection against infection after two Oxford/AstraZeneca jabs fell from 77% to 67% at four to five months.
Not true. You can easily take Jensen in Germany, and in consultation with a doctor, the Astrazeneca vaccine.Not in Germany.
Multiple effects at work I think. Pfizer is less effective against Delta than Alpha, and it was less effective against Alpha than against the Spring 2020 version (that the phase 3 data came from). The lab studies, the PHE surveillance etc all agree on those losses, but they're relatively small and protection against severe illness remains high.@jojojo
Or anyone else who is deep into all this stuff. Is it just me or is all this “waning immunity” stuff not taking into account something really obvious?
Surely the proportion of cases due to Delta has increased massively between the first one or two months after vaccination and five to six months? It’s not like the vaccines have been out all that long. So most people hitting six months post jab are getting infected at a time when they’re catching Delta. While all the earlier, much higher, efficacy stats were generated when alpha was the only show in town.
So couldn’t all these concerns about waning immunity be entirely down to vaccines being a bit less effective against delta than alpha? A trend that boosters might not reverse?
I'm with you, sort of. I am not convinced the boosters are necessary. While antibodies are great and all what matters is memory cells. Our bodies don't keep high titers of antibodies floating around for everything we have ever encountered, that would just be stupid and is simply not how our immune systems work. As long as we are forming a long lasting, and robust, memory response to COVID we are fine. It is this response that, while it will most likely not prevent infection, will reduce the likelihood for severe symptoms and hospitalization. This is why the whole "OMG! I had the vaccine and I still got (asymptomatic) COVID! The vaccines don't work!" is so maddening. That is not how these things are supposed to work! Ugh. My (previous) profession is so bad a messaging and the general public is so bad a listening.@jojojo
Or anyone else who is deep into all this stuff. Is it just me or is all this “waning immunity” stuff not taking into account something really obvious?
Surely the proportion of cases due to Delta has increased massively between the first one or two months after vaccination and five to six months? It’s not like the vaccines have been out all that long. So most people hitting six months post jab are getting infected at a time when they’re catching Delta. While most of the earlier, much higher, efficacy stats were generated when alpha was the only show in town.
So couldn’t all these concerns about waning immunity be entirely down to vaccines being a bit less effective against delta than alpha? A trend that boosters might not reverse?
From a pure science perspective the difference in Pfizer/Moderna is fascinating. They are using the same protein sequence for their vaccine, with the only differences being in the leading and trailing portions of the mRNA strand and the carrier nanoparticles. There is so much to learn from this to optimize the next generation of mRNA vaccines!Multiple effects at work I think. Pfizer is less effective against Delta than Alpha, and it was less effective against Alpha than against the Spring 2020 version (that the phase 3 data came from). The lab studies, the PHE surveillance etc all agree on those losses, but they're relatively small and protection against severe illness remains high.
It's also getting harder to obtain genuine matched control groups for doing effectiveness calculations. The higher the percentage vaccinated, the smaller the comparison group gets. Meanwhile, as more people catch covid, the number of actual immune-naive people is reduced, but we don't know by how much. Now throw in the fact that many of the unvaxxed will also be people who don't want to get tested and the confounding factors just keep rising.
Which brings us to Israel and the additional problem of moving the goalposts. The vaccine trials reported on symptomatic infection, with testing done in response to symptoms and efficacy reported against symptomatic infection. They weren't chasing data on asymptomatic infection. Once we talk about infection/transmission prevention we're asking the vaccines a different question.
Because of how good the vaccines are, people started expecting them to stop infections and it looks like while we're still flooded with the first flush of vaccine induced antibodies they do pretty well at it. Israel's data suggests that once those heavy antibody levels fall so does that inhibition on infection.
We also know that Delta has shorter delays from infection to symptom onset. Maybe the immune memory cells come in to antibody producing action too slowly to stop the infection before it gets a strong enough hold to test positive on PCR and show up as symptoms?
If we're chasing having high levels of covid neutralising antibodies all the time we will need boosters - but I must admit I'm not convinced that's a good or (for most of the population) necessary road to go down.
I actually don't see the waning immunity. Lower levels of antibodies are not a problem as @WI_Red pointed out.@jojojo
Or anyone else who is deep into all this stuff. Is it just me or is all this “waning immunity” stuff not taking into account something really obvious?
Surely the proportion of cases due to Delta has increased massively between the first one or two months after vaccination and five to six months? It’s not like the vaccines have been out all that long. So most people hitting six months post jab are getting infected at a time when they’re catching Delta. While most of the earlier, much higher, efficacy stats were generated when alpha was the only show in town.
So couldn’t all these concerns about waning immunity be entirely down to vaccines being a bit less effective against delta than alpha? A trend that boosters might not reverse?
I don't know much about biontech but I'm impressed with Moderna. Obviously I think mRNA technology is revolutionary for medicine. Question is which of these two companies is better? If one is better to begin with.From a pure science perspective the difference in Pfizer/Moderna is fascinating. They are using the same protein sequence for their vaccine, with the only differences being in the leading and trailing portions of the mRNA strand and the carrier nanoparticles. There is so much to learn from this to optimize the next generation of mRNA vaccines!
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In about a month or so I think we'll have more clearer evidence regarding booster shots possiblyAfter 16 days, a third coronavirus vaccine dose boosts protection against severe illness from the virus to 97 percent, according to Health Ministry figures cited by Channel 12 news on Wednesday night.
The network also said that 16 days after the booster shot is administered, protection against infection jumps to 95%. According to the report, while the level of antibodies is considerably higher within seven days of the shot, they appear to reach their peak after 16 days.
More than 1.7 million Israelis have received a booster dose since the shots first became available on August 1. As of Tuesday, the third doses are available to all Israelis over the age of 30. More than 70% of those over the age of 70 have already received a third dose of the vaccine.
Wow. Didn’t realise they were boosting everyone over 30. If that efficacy vs infection persists they could get close to herd immunity.https://www.timesofisrael.com/covid-booster-shots-raise-protection-against-severe-illness-to-97-tv/
In about a month or so I think we'll have more clearer evidence regarding booster shots possibly