The vaccines | vaxxed boosted unvaxxed? New poll

[Paul the Wolf]

Here they're recalling people exactly 3 weeks after the first Pfizer jab, going by oates's experience. Mind you, it's why things are taking so long in Italy - they are making sure that people get their second vaccinations, rather than giving one jab to more people.

I'm not sure if it's the right approach, in general. It seems to me that it's better to give more people some protection.

Originally the gap was four weeks but the french government wanted to give more people their first jabs so extended it by two weeks. I booked both first and second jabs for me and the wife online last week and they re-confirmed our second jabs today.
We had the choice of Pfizer or Moderna at the vaccination centres, although they are low on Moderna doses at present or we could choose between the AZ or the JJ which is now slowly being rolled out at our doctors or at the pharmacy.
After a slow start things are progressing well here.

 

[jojojo]

Another one for the enthusiasts. I've been grubbing around for more background on how the mRNA vaccines are made - in particular an explanation of the short production time of the mRNA element itself and the role of the specialised lipids suppliers. Just a nice article to give you a sense of what a vaccine needs to do to increase production.
https://blogs.sciencemag.org/pipeline/archives/2021/02/02/myths-of-vaccine-manufacturing

In fact there are a whole bunch of vaccine related interesting articles on that blog, if you're willing to dig - if you like that sort of thing
https://blogs.sciencemag.org/pipeline/

 

[Pogue Mahone]

Another one for the enthusiasts. I've been grubbing around for more background on how the mRNA vaccines are made - in particular an explanation of the short production time of the mRNA element itself and the role of the specialised lipids suppliers. Just a nice article to give you a sense of what a vaccine needs to do to increase production.
https://blogs.sciencemag.org/pipeline/archives/2021/02/02/myths-of-vaccine-manufacturing

In fact there are a whole bunch of vaccine related interesting articles on that blog, if your willing to dig - if you like that sort of thing
https://blogs.sciencemag.org/pipeline/

That’s a great read. Dumbed down just the right amount. The technology really is mind-blowing.

 

[Penna]

Originally the gap was four weeks but the french government wanted to give more people their first jabs so extended it by two weeks. I booked both first and second jabs for me and the wife online last week and they re-confirmed our second jabs today.
We had the choice of Pfizer or Moderna at the vaccination centres, although they are low on Moderna doses at present or we could choose between the AZ or the JJ which is now slowly being rolled out at our doctors or at the pharmacy.
After a slow start things are progressing well here.

Yes, France seems to be winning as far as European countries are concerned. In Italy, they're having to shut-down some vaccination centres at the moment because they've run out of vaccines. People all over the country have been turning up for appointments and finding places unstaffed and closed.

It's been availability that's been the main problem here, together with many people getting vaccinated when they weren't entitled to have it at the start of the roll-out. That was due to the government prioritising by occupational groups in the early days, which were too broad in definition and were also easy to scam. Evidently 3.1 million people got vaccinated on the basis of being health workers! Anything that's not based on your date of birth is open to cheating, really.

They've now largely reverted to an age-based plan, although oates and I are in two smaller priority groups because of his health issues and the fact that I live with him. I registered over a week ago on the day my group was open for bookings in our region, but I've not heard anything yet. I'll be 63 next week and I wouldn't be eligible yet based just on my age.

 

[zing]

https://www.agglomerations.tech/how-the-us-can-solve-the-global-vaccine-shortfall/

This on the vaccine IP issue is a great read.

 

[11101]

Yes, France seems to be winning as far as European countries are concerned. In Italy, they're having to shut-down some vaccination centres at the moment because they've run out of vaccines. People all over the country have been turning up for appointments and finding places unstaffed and closed.

It's been availability that's been the main problem here, together with many people getting vaccinated when they weren't entitled to have it at the start of the roll-out. That was due to the government prioritising by occupational groups in the early days, which were too broad in definition and were also easy to scam. Evidently 3.1 million people got vaccinated on the basis of being health workers! Anything that's not based on your date of birth is open to cheating, really.

They've now largely reverted to an age-based plan, although oates and I are in two smaller priority groups because of his health issues and the fact that I live with him. I registered over a week ago on the day my group was open for bookings in our region, but I've not heard anything yet. I'll be 63 next week and I wouldn't be eligible yet based just on my age.

There are 5 million doses coming between now and 5th May.

We don't seem to be having those problems here. There is capacity to give more vaccines but we are still managing the government's target of 70-100k per day. The only issue is they are stopping new AZ doses until at least May 19.

 

[Penna]

There are 5 million doses coming between now and 5th May.

We don't seem to be having those problems here. There is capacity to give more vaccines but we are still managing the government's target of 70-100k per day. The only issue is they are stopping new AZ doses until at least May 19.

I expect the more populous (and influential) north of the country got some priority. I hope we start getting a regular supply to every region soon, the vaccination plan is at different stages depending on where you live.

 

[RoyH1]

Ah don’t worry we don’t do that anymore

 

[Paul the Wolf]

Yes, France seems to be winning as far as European countries are concerned. In Italy, they're having to shut-down some vaccination centres at the moment because they've run out of vaccines. People all over the country have been turning up for appointments and finding places unstaffed and closed.

It's been availability that's been the main problem here, together with many people getting vaccinated when they weren't entitled to have it at the start of the roll-out. That was due to the government prioritising by occupational groups in the early days, which were too broad in definition and were also easy to scam. Evidently 3.1 million people got vaccinated on the basis of being health workers! Anything that's not based on your date of birth is open to cheating, really.

They've now largely reverted to an age-based plan, although oates and I are in two smaller priority groups because of his health issues and the fact that I live with him. I registered over a week ago on the day my group was open for bookings in our region, but I've not heard anything yet. I'll be 63 next week and I wouldn't be eligible yet based just on my age.

France gave priority to the OAP /care homes and medical /strategic workers and people at high risk and are now working through the age groups.
Currently 60+ for Pfizer & Moderna , both of which have been available since vaccination started and now at vaccination centres, which in our case is at the medical centre in a nearby small town. (our age group)
The 55+ group can book AZ & JJ at their GP or Pharmacy. There is hesitancy concerning the last two but all the appointments have been taken.

I made our appointments the day they became available by checking on line every hour throughout the day but they quickly went and now I believe there's a several weeks waiting list.

The vaccination centre has plenty of volunteer staff , we're in a low populated area, it was all very well done.

Touch wood, I have had no effects in the first 24 hours but my wife's arm aches a bit

 

[Kopral Jono]

I took my second jab this morning. Sinovac. The first time I felt fine, minor throbbing pain on injection site aside. This time around I felt a bit drowsy a few hours after, which went away after a short nap, and my upper left arm is feeling very sore with movement.

I guess it's just the vaccine doing its thing.

 

[Pogue Mahone]

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I don’t even...

 

[GloryHunter07]

I cant say i am even remotely surprised Russia is acting the fool here. Some people just want to watch the world burn.

 

[jojojo]

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I don’t even...

Having defended Sputnik from the "can you really trust what they say" thing, following their release of Phase 3 interim data, they aren't half making me backtrack.

 

[stu_1992]

France gave priority to the OAP /care homes and medical /strategic workers and people at high risk and are now working through the age groups.
Currently 60+ for Pfizer & Moderna , both of which have been available since vaccination started and now at vaccination centres, which in our case is at the medical centre in a nearby small town. (our age group)
The 55+ group can book AZ & JJ at their GP or Pharmacy. There is hesitancy concerning the last two but all the appointments have been taken.

I made our appointments the day they became available by checking on line every hour throughout the day but they quickly went and now I believe there's a several weeks waiting list.

The vaccination centre has plenty of volunteer staff , we're in a low populated area, it was all very well done.

Touch wood, I have had no effects in the first 24 hours but my wife's arm aches a bit

I hope this continues to see a big uptake of the vaccine as I was a little concerned at the first signs of some slots not being filled from a article I saw Monday. 227,000 vaccinations slots were still available Monday apparently.

https://www.letelegramme.fr/bretagn...s-preneur-en-bretagne-27-04-2021-12741485.php

 

[Paul the Wolf]

I hope this continues to see a big uptake of the vaccine as I was a little concerned at the first signs of some slots not being filled from a article I saw Monday. 227,000 vaccinations slots were still available Monday apparently.

https://www.letelegramme.fr/bretagn...s-preneur-en-bretagne-27-04-2021-12741485.php

When I was at the vaccination centre yesterday there were people phoning up who were clearly unsure of how to book their appointments by listening to the replies of the staff, especially the older patients.
As the age groups get younger I would expect younger people would be more internet literate and understand more easily how to reserve their vaccines.

 

[jojojo]

https://www.agglomerations.tech/how-the-us-can-solve-the-global-vaccine-shortfall/

This on the vaccine IP issue is a great read.

It's a good article on the broad principles. Certainly, when it comes to pandemic preparedness, the ability to manufacture the new generation of vaccines globally is crucial. I think it underestimates the timeline for that though.

The role of individual engineers/scientists shouldn't be underestimated when it comes to production knowledge transfer. The Pfizer plant have now been through the production loop lots of times, maybe even dozens and will have undergone multiple tuning steps to get to safe running capacity. The actual number of key people involved in that design tuning/process tweaking will have been tiny though.

Some of them may now be able to go and create a similar line elsewhere. But it would still take months to modify an existing factory - and shortages on raw materials, components, and freezer technology might still interfere. It's arguable a better use of their time would be to create a kit that could be cloned for future use.

On AZ and J&J. Well, J&J had already said their IP is available to anyone who can use it - but they've had trouble getting their own facilities up to full production. As far as I know only one of the European plants has reached production volume so far - I'd suggest they don't yet know enough to know-how share.

The same's true for Novavax (though that's a different technology again). All the indications there are that they're still learning how to make it.

SII are the biggest producer of the Oxford/AZ vaccine. It's already being produced on multiple sites globally, and it probably could have gone wider if it hadn't had quite so many issues (and such terrible PR). I'm happy to argue that AZ remains a good option for most of the world, but its rejection by South Africa (where its performance against the variant looked weak in trials) will make it a tough sell to other countries and to potential manufacturers.

 

[klsv]

Finally got my first shot of Pfizer on Sunday, bless my asthma and hypertension for placing me into the risk group! Felt nothing for a few hours, then fell asleep during our match against Leeds. Thought it was just how wank the game was but once I woke I was really cold and still sleepy. Only got a slight fever during the night and in the morning I felt like I was beaten with an iron rod all night Took a glass of whiskey with my morning coffee and fecked off back to bed. Yesterday I woke up feeling absolutely fantastic. My mom's a nurse so she has had two shots of AZ already, my dad will get his second shot of Pfizer next week. Can finally breathe easy and knowing we can watch the Euros together at their place soon makes me so happy!

 

[Classical Mechanic]

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I don’t even...

Having defended Sputnik from the "can you really trust what they say" thing, following their release of Phase 3 interim data, they aren't half making me backtrack.

It all feels very Soviet doesn't it.

 

[stu_1992]

When I was at the vaccination centre yesterday there were people phoning up who were clearly unsure of how to book their appointments by listening to the replies of the staff, especially the older patients.
As the age groups get younger I would expect younger people would be more internet literate and understand more easily how to reserve their vaccines.

Hmm yeah good point. I was concerned that, as we were maybe starting to reach some of the younger people, we may see a bigger impact of the perceived vaccine skeptics in this country. Obviously there was a lot of polls ahead of the vaccination campaign and in the early days that showed relatively low numbers for people being willing to get vaccinated in France, but so far that doesn't seem to be reflected in the vaccine campaign.

 

[RoyH1]

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I don’t even...

As long as there is chaos and disagreement in "the West", Putin and his regime are happy. They must have been watching with absolute glee when the EU and the UK were engaged in a war of words because of AZ shortages.

 

[golden_blunder]

Wife got moderna this morning. Sore arm so far.

told that’s what I will get tomorrow

 

[Pogue Mahone]

It's all feels very Soviet doesn't it.

State run misinformation campaign on social media. Classic. So fecking evil in this context.

 

[Sweet Square]

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[fergosaurus]

UK Orders 60m Extra Pfizer Doses For Covid Booster Jabs

The booster programme is set to begin in the autumn. An extra 60m doses of the Pfizer/BioNTech vaccine have been secured by the government for Covid-19 booster jabs, Matt Hancock has announced.

 

[christinaa]

Wife got moderna this morning. Sore arm so far.

told that’s what I will get tomorrow

Is it the first dose?

 

[Ajr]

Getting mine on Thurs

 

[golden_blunder]

Is it the first dose?

Yes. Her arm is killing her tonight but no fever or anything like that so far

 

[christinaa]

Yes. Her arm is killing her tonight but no fever or anything like that so far

I had both Moderna doses.
The first one only gave me pain in the arm but the second one was much worse unfortunately.

 

[golden_blunder]

I had both Moderna doses.
The first one only gave me pain in the arm but the second one was much worse unfortunately.

I have to get the first tomorrow
Are you feeling better now?

 

[Sir Matt]

This story on how the Pfizer vaccine is made is incredibly interesting and also shows the sizable constraints on manufacturing an mRNA vaccine (namely all of the source DNA comes from one plant and is then sent to other plants for processing).

https://www.nytimes.com/interactive/2021/health/pfizer-coronavirus-vaccine.html

Having defended Sputnik from the "can you really trust what they say" thing, following their release of Phase 3 interim data, they aren't half making me backtrack.

It seems the production of Sputnik is, somewhat unsurprisingly, a dumpster fire. As this thread explains, the Sputnik manufacturing process apparently didn't delete the gene controlling replication of the adenovirus so the Sputnik samples that Brazil and Slovakia have received are of vaccines that will replicate after injected.

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[christinaa]

I have to get the first tomorrow
Are you feeling better now?

Yesterday i was better but it took 2 days of feeling unwell and night chills.
Although i may say that the vaccine doesn't effect everyone in the same way as some friends didn't have any symptoms while other swere much worse than me - same age group and same vaccine. Strange.

 

[jojojo]

This story on how the Pfizer vaccine is made is incredibly interesting and also shows the sizable constraints on manufacturing an mRNA vaccine (namely all of the source DNA comes from one plant and is then sent to other plants for processing).

https://www.nytimes.com/interactive/2021/health/pfizer-coronavirus-vaccine.html

That's a really good article, and gives a nice handle on the timeline of the process - including those long pauses as the vaccine waits for quality tests to complete.

One of the documents from EMA that was leaked when they got hacked before Christmas gives an interesting "regulator's eye view" of the product. Their responsibility doesn't end once they've the clinical trial data. Their next job is to see if the manufactured product is the same as the product trialled (composition, concentration, integrity, contaminants) - and in the early Pfizer production it wasn't quite there. Ramping up from trial size batches to product is not easy:
https://www.bmj.com/content/372/bmj.n627

 

[jojojo]

After the jabs - a survey of 627,383 people reporting their reactions/symptoms after their covid jabs. The most common side-effect was some pain or tenderness in the injected arm - more than half the recipients experienced that. The next most common was headache/fatigue - around a quarter of the group experienced that, typically mild and lasting a day or so.

Interestingly the reported real world rates are lower than the clinical trial reported rates.

https://www.bbc.co.uk/news/health-56901356

 

[Traub]

UK Orders 60m Extra Pfizer Doses For Covid Booster Jabs

The booster programme is set to begin in the autumn. An extra 60m doses of the Pfizer/BioNTech vaccine have been secured by the government for Covid-19 booster jabs, Matt Hancock has announced.

Good news for UK, bad news for the rest of the world - not because of UK specifically, but I fear USA and EU will jump on this bandwagon pushing the third world even further behind. It's going to be sad to see the entire UK, EU and USA populations receiving their second Covid vaccines whilst a lot of the rest of the world is waiting for their first.

 

[11101]

Good news for UK, bad news for the rest of the world - not because of UK specifically, but I fear USA and EU will jump on this bandwagon pushing the third world even further behind. It's going to be sad to see the entire UK, EU and USA populations receiving their second Covid vaccines whilst a lot of the rest of the world is waiting for their first.

The EU has already made a massive order for booster doses, but from next year.

The UK needs to switch everybody over to Pfizer because it's easier to update for new variants and doesn't face vector immunity issues. Plus, it seems like it works better against new variants it's not been adapted for.

 

[jojojo]

Good news for UK, bad news for the rest of the world - not because of UK specifically, but I fear USA and EU will jump on this bandwagon pushing the third world even further behind. It's going to be sad to see the entire UK, EU and USA populations receiving their second Covid vaccines whilst a lot of the rest of the world is waiting for their first.

The key now is going to be how fast production can go up globally. Which in turn still depends a lot on J&J and AZ. Pfizer are already expecting to produce massively more vaccine doses than they originally planned, and have deals with people like Sanofi to do it.

By Q3/4 we should be seeing Novavax and Curevac - both of which have the potential to offer fridge temperature vaccines, and high production volumes. But like all potential, we won't know what we've really got until they're actually out there.

There are lots of other potentials out there as well. There's an intriguing Cuba/China project underway for example. If it can avoid some of the pitfalls of some of the other Chinese vaccines that could be a real boost to the world.

My own guess is that we'll see multiple countries including the UK and the US giving away (or simply postponing deliveries) of their excess supply during Q3 and that there will be a lot of vaccine doses available globally in Q4. Unfortunately that prediction depends on all the vaccines remaining acceptable (efficacy and safety).

 

[Pexbo]

Good news for UK, bad news for the rest of the world - not because of UK specifically, but I fear USA and EU will jump on this bandwagon pushing the third world even further behind. It's going to be sad to see the entire UK, EU and USA populations receiving their second Covid vaccines whilst a lot of the rest of the world is waiting for their first.

It will end up a vicious cycle where the first world continually vaccinated themselves against new variants while the third world acts as a breeding ground for new variants.

 

[Pogue Mahone]

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First step to the Holy Grail completed. A vaccine that provides immunity against all coronaviruses. Will work against any and all future variants of SARS-COV-2 as well as any nasty new coronaviruses which might be brewing up in a pangolin’s arse in a jungle somewhere.

 

[Pexbo]

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First step to the Holy Grail completed. A vaccine that provides immunity against all coronaviruses. Will work against any and all future variants of SARS-COV-2 as well as any nasty new coronaviruses which might be brewing up in a pangolin’s arse in a jungle somewhere.

Holy shit that’s incredible. Any chance this could be done for Rhinoviruses too?

 

[ha_rooney]

Apologies if this has already been answered, but have they said that those people who had the AZ vaccine will also be able to take the Pfizer booster shot or are they expected to wait for a AZ booster?