SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

Pogue Mahone

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Back to school for covid. Just a cautionary note for the next few weeks.


It's worth looking at the whole thread, interesting info from around the world.
That makes grim reading.

This subtweet is particularly scary. This UK variant is a frigging nightmare.

 

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Side note. Makes you wonder if vaccine schedule should change? Adults with kids vaccinated before adults without kids?

Based on that data seems like a no-brainer. Would be an incredibly unpopular decision though!
For that to be necessary I would have expected to see a higher than average rate of covid hospitalisation or death in teachers and child care workers, but I'm not sure anyone has shown that to be the case, as it is with high risk groups like factory, care home, transport and retail workers?

Maybe bumping overweight people up the priority list would actually save more lives?
 

jojojo

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Side note. Makes you wonder if vaccine schedule should change? Adults with kids vaccinated before adults without kids?

Based on that data seems like a no-brainer. Would be an incredibly unpopular decision though!
The issue for the UK is that we've got a lot of those kind of disproportionate impact things. Occupational ones like taxi drivers etc; poverty; social ones like multigenerational living. We know enough to see it, but not enough to see if it really does more to bring down the death/hospitalisation toll than the current age/medical risk ones.

Once we get to the under 50s, I suspect there will be more arguments. Personally I think we're likely to see some postcode targeted scheduling, but I don't know about what else they'll do. The good thing about the current UK system is that it "sounds fair" and it's relatively straightforward to administer.

Anything new would throw up new anomalies - yes, mum and dad are covered, but what about 45 year old granny who picks them up from school etc etc. If everyone's a priority, no one is - let's hope the vaccines keep working and the suppliers keep delivering (in steadily increasing quantity)
 

Pogue Mahone

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For that to be necessary I would have expected to see a higher than average rate of covid hospitalisation or death in teachers and child care workers, but I'm not sure anyone has shown that to be the case, as it is with high risk groups like factory, care home, transport and retail workers?

Maybe bumping overweight people up the priority list would actually save more lives?
Overweight people are being bumped up though. They’re already considering high risk.

Re teachers vs other jobs, I wonder if that’s because this new Uk variant is a bigger issue with kids than the previous ones? Schools have been basically closed since before Christmas, so teachers haven’t been at risk. Unlike Danish parents, evidently.
 

Pogue Mahone

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The issue for the UK is that we've got a lot of those kind of disproportionate impact things. Occupational ones like taxi drivers etc. Social ones like multigenerational living. We know enough to see it, but not enough to see if it really does more to bring down the death/hospitalisation toll than the current age/medical risk ones.

Once we get to the under 50s, I suspect there will be more arguments. Personally I think we're likely to see some postcode targeted scheduling, but I don't know about what else they'll do. The good thing about the current UK system is that it "sounds fair" and it's relatively straightforward to administer.

Anything new would throw up new anomalies - yes, mum and dad are covered, but what about 45 year old granny who picks them up from school etc etc. If everyone's a priority, no one is - let's hope the vaccines keep working and the suppliers keep delivering (in steadily increasing quantity)
No system will be perfect. For me the Uk approach gets one piece wrong, which is not prioritising the young ahead of the young middle-aged. Looking at the age profile of cases and large outbreaks it arguably makes more sense to vaccinate 40 year olds after 20 year olds, for example.

With occupational prioritising it gets very messy but if this Danish data is to be believed (and I haven’t read it in detail, just the headlines) then if your occupation is “parent” that puts your risk ahead of all others.
 

Pogue Mahone

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FFS. I wish I hadn’t discovered this guy’s twitter feed now.

Anyhoo. This P1 variant is the final nail in the coffin of the Swedish herd immunity strategy. Looks as though Brazil is having to go through the first wave all over again, with prior infection giving little protection against the new variant. Grim.
 

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Side note. Makes you wonder if vaccine schedule should change? Adults with kids vaccinated before adults without kids?

Based on that data seems like a no-brainer. Would be an incredibly unpopular decision though!
Get fecked with that!

Also makes no sense from an economic perspective as adults without kids are likely to take far more holidays and trips once they can.
 
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Also makes no sense from an economic perspective as adults without kids are likely to take far more holidays and trips once they can.
Serious?

My trips pre-kid were plenty, but cheap as feck. For a start you'd never go during school holidays when prices are beyond belief, post kid and your few hundred quid holiday suddenly turns into thousands.
 

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Side note. Makes you wonder if vaccine schedule should change? Adults with kids vaccinated before adults without kids?

Based on that data seems like a no-brainer. Would be an incredibly unpopular decision though!
Everyone will be vaccinated by mid-late June anyway (In the U.K.) - by the time we managed to get the data to even do that which would be incredibly difficult - there’s no link between NHS number and how many kids you have - it’ll all be over. That’s why they decided to stick with age and not job role or any other permutation - it’s far easier and quicker.
 

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Overweight people are being bumped up though. They’re already considering high risk.

Re teachers vs other jobs, I wonder if that’s because this new Uk variant is a bigger issue with kids than the previous ones? Schools have been basically closed since before Christmas, so teachers haven’t been at risk. Unlike Danish parents, evidently.
Ah right. The virus might be running faster than the data, as ever. We'll know more some time after re-opening of course.
 

Pogue Mahone

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Everyone will be vaccinated by mid-late June anyway (In the U.K.) - by the time we managed to get the data to even do that which would be incredibly difficult - there’s no link between NHS number and how many kids you have - it’ll all be over. That’s why they decided to stick with age and not job role or any other permutation - it’s far easier and quicker.
Fair enough. Mass simultaneous school opening will test that strategy but c’est la vie. Be something for the UK to think about for boosters/new variant vaccines anyway. To get a list of parents you could presumably approach the schools. For the rest of us, something to think about right now.
 
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Massive Spanner

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You think? Go to an average holiday resort during school holidays and again during term. You’ll see how big a driver families are of tourism.
Right but that's at limited parts of the year. Couples and young people without kids can go at any time of the year, plus by the time we get regular adults vaccinated summer will be over anyway! Absolutely no chance people with kids are bigger drivers of tourism than people without. Then you have all the weddings that have been delayed, getting them back going would be absolutely huge for hotels.

Anyway it's a terrible idea. At least people with kids have their kids (for better or worse). What about adults who are stuck by themselves or shitty flatmates? Imagine telling them they have to wait to get vaccinated when they're probably already in an awful state of mind. Not everyone without kids is living with their other half happy out after all.
 

Massive Spanner

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Serious?

My trips pre-kid were plenty, but cheap as feck. For a start you'd never go during school holidays when prices are beyond belief, post kid and your few hundred quid holiday suddenly turns into thousands.
But again that's all very limited. When you've kids generally you're stuck going at certain times of year to certain resorts in certain areas. Here in Ireland we have loads of tourist towns that would benefit far more from people without kids being able to go, especially with a tourism culture that's so reliant on alcohol, pubs, hotel bars etc. Then you've all the stags, hens, weddings bla bla. There's no comparison. Plus people without kids are more likely to go back to the office instead of work remotely too given they've less commitments which means more money being spent in city centers again.

But you both have kids so I can see why you're trying to peddle this narrative ;)
 

Pogue Mahone

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Right but that's at limited parts of the year. Couples and young people without kids can go at any time of the year, plus by the time we get regular adults vaccinated summer will be over anyway! Absolutely no chance people with kids are bigger drivers of tourism than people without. Then you have all the weddings that have been delayed, getting them back going would be absolutely huge for hotels.

Anyway it's a terrible idea. At least people with kids have their kids (for better or worse). What about adults who are stuck by themselves or shitty flatmates? Imagine telling them they have to wait to get vaccinated when they're probably already in an awful state of mind. Not everyone without kids is living with their other half happy out after all.
It’s shit for everyone. In different ways. And there will be people taking lockdown worse than others in every possible category. Prioritising parents wouldn’t be about targeting the people worst affected by lockdown, though, it would be trying to prevent the people most likely to catch the virus from passing it on to others. It would also help kids in school, which is one of the priorities we’ve agreed on as a society.

This is all very hypothetical though. Just a thought, based on a single tweet. I have no idea how reliable that Danish data is.
 

Massive Spanner

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It’s shit for everyone. In different ways. And there will be people taking lockdown worse than others in every possible category. Prioritising parents wouldn’t be about targeting the people worst affected by lockdown, though, it would be trying to prevent the people most likely to catch the virus from passing it on to others. It would also help kids in school, which is one of the priorities we’ve agreed on as a society.

This is all very hypothetical though. Just a thought, based on a single tweet. I have no idea how reliable that Danish data is.
Eh, have we? I don't recall agreeing to it. Though for a start maybe we should vaccinate the teachers before looking at the kid's parents.

I think people getting preferential treatment because they have kids would be a disaster. People are already fed up of this lockdown and we're seeing loads of idiots swarm the streets, imagine how much worse that would be if they were told they will be getting vaccines months after others just cause they don't have kids in school? Young people would probably give even less of a feck about the current restrictions than they currently do. Not worth it, terrible idea, down with this sort of thing.
 

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Eh, have we? I don't recall agreeing to it. Though for a start maybe we should vaccinate the teachers before looking at the kid's parents.

I think people getting preferential treatment because they have kids would be a disaster. People are already fed up of this lockdown and we're seeing loads of idiots swarm the streets, imagine how much worse that would be if they were told they will be getting vaccines months after others just cause they don't have kids in school? Young people would probably give even less of a feck about the current restrictions than they currently do. Not worth it, terrible idea, down with this sort of thing.
I'm not sure I count as young anymore, but I know I'm in the lowest priority band anyway so I'm not sure I'm massively bothered about what the precise order is of people who receive the vaccine before me. Either way, I'm going to be left with a massive sense of FOMO if you're all off having fun and I have to sit inside and wait for a vaccine to tick a box on an app or whatever.
 

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It’s shit for everyone. In different ways. And there will be people taking lockdown worse than others in every possible category. Prioritising parents wouldn’t be about targeting the people worst affected by lockdown, though, it would be trying to prevent the people most likely to catch the virus from passing it on to others. It would also help kids in school, which is one of the priorities we’ve agreed on as a society.

This is all very hypothetical though. Just a thought, based on a single tweet. I have no idea how reliable that Danish data is.
Not only not knowing how reliable it is but also it is just fact stating. No external and/or latest circumstances being taken into consideration, i.e. the vaccination processes of different countries particularly the UK.

Basically akin to reading yesterday's foreign newspaper in which the fish and chips was wrapped in.
 

Pogue Mahone

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Not only not knowing how reliable it is but also it is just fact stating. No external and/or latest circumstances being taken into consideration, i.e. the vaccination processes of different countries particularly the UK.

Basically akin to reading yesterday's foreign newspaper in which the fish and chips was wrapped in.
Basically nothing like that.
 

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Basically nothing like that.
Fair enough. But hasn't the latest AZ study shown it is already somewhat effective against the Brazilian strain? Read it this morning on the BBC.

If that's the case, with the majority of Brits injected with AZ, then even 'somewhat effective' means our immune systems will be better equipped to handle the serious effects of P1, right?

So we're comparing apples (what's happening in Brazil) with oranges (UK)?
 

Don't Kill Bill

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Fair enough. But hasn't the latest AZ study shown it is already somewhat effective against the Brazilian strain? Read it this morning on the BBC.

If that's the case, with the majority of Brits injected with AZ, then even 'somewhat effective' means our immune systems will be better equipped to handle the serious effects of P1, right?

So we're comparing apples (what's happening in Brazil) with oranges (UK)?
I hope so I just had the inoculation an hour ago.
 

Reddevildans

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With schools opening on Monday. We can expect an increase in cases by the 3rd week of march onwards. But if the link between cases and admissions is severed we should expect less hospitalizations and then death. Lets bloody hope so!
 

Pogue Mahone

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Fair enough. But hasn't the latest AZ study shown it is already somewhat effective against the Brazilian strain? Read it this morning on the BBC.

If that's the case, with the majority of Brits injected with AZ, then even 'somewhat effective' means our immune systems will be better equipped to handle the serious effects of P1, right?

So we're comparing apples (what's happening in Brazil) with oranges (UK)?
No and no.

The Danish study I was referring to (re parents being much more at risk) was about the UK strain.

There’s no evidence that any vaccine works against the Brazilian (P1) strain. You might be getting confused with the South African strain?

Johnson & Johnson’s vaccine had 57% efficacy in South Africa, where the variant is prevalent, versus 72% in the US, and Novavax’s vaccine had 49% efficacy in South Africa versus 90% in the UK. The “older” vaccines (including AZ) don’t have much useful data against this strain as it wasn’t around when they ran their big phase III trials. There was one small, more recent, study testing the AZ vaccine in South Africa which showed such disappointing results the South African government decided not to use it.

The P1strain in Brazil is even more recent and I don’t think we have any evidence of any vaccine working against it. It has similar mutations to the South African strain so the vaccines that work against that strain might work against the P1 variant (and the ones that don’t work might not work against this one either) But we don’t know yet. What we do know is that past infection with ‘original’ covid seems to give very little protection, hence Manaus (and loads of other regions in Brazil) is going through another massive surge, despite having enough prior infections that they should be close to herd immunity.
 

lynchie

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FFS. I wish I hadn’t discovered this guy’s twitter feed now.

Anyhoo. This P1 variant is the final nail in the coffin of the Swedish herd immunity strategy. Looks as though Brazil is having to go through the first wave all over again, with prior infection giving little protection against the new variant. Grim.
Honestly, you can generally ignore him. He's a joke among all the (weirdly large number of) infectious disease experts I've followed over the last year.
 

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Honestly, you can generally ignore him. He's a joke among all the (weirdly large number of) infectious disease experts I've followed over the last year.
I ignore him because he's the ultimate bearer of bad news. I can't vouch for his credibility but anytime I've seen him on here he leaves me with a sense of dread.
 

lynchie

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With schools opening on Monday. We can expect an increase in cases by the 3rd week of march onwards. But if the link between cases and admissions is severed we should expect less hospitalizations and then death. Lets bloody hope so!
Last time we had lockdown with schools open, cases dropped, so there's no certainty that cases will rise. They might drop more slowly than they otherwise would have, but we're starting at a pretty low baseline, and primary school age kids currently have the lowest rate of infection of any age group, so are the lowest risk group to relax restrictions on.
 

Pogue Mahone

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Honestly, you can generally ignore him. He's a joke among all the (weirdly large number of) infectious disease experts I've followed over the last year.
Excellent. I’m trying to keep off Twitter to avoid having my mood soured like that. Appreciate you separating the wheat and chaff. It’s amazing how easy it is to get sucked into a doom spiral by carefully cherry picked worrying looking data.

Is he a joke for being constantly overly negative?
 

Dan_F

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Is obviously wrong but did the public know that much about the benefits of/need for masks on March 4? I don't remember feeling that was the case.

Edit - Just went back through the thread and Elvz posted a tweet on March 4 saying we'd had a recorded 85 in total cases. How crazy does that seem now?!
Probably not, but logic would say that if you cover your nose and mouth, you’re less likely likely to pass stuff on. Most people did that already when they sneeze for example.

I’m more than happy to continue wearing masks in shops after this is done, and also avoid hand shakes. I haven’t had so much as a blocked nose for a year now.
 

lynchie

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Excellent. I’m trying to keep off Twitter to avoid having my mood soured like that. Appreciate you separating the wheat and chaff. It’s amazing how easy it is to get sucked into a doom spiral by carefully cherry picked worrying looking data.

Is he a joke for being constantly overly negative?
Partly his ridiculous negative bias, but also largely that he often indicates that he doesn't really understand the studies he's shouting about.
 

Pogue Mahone

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To be honest, wish I had the willpower to stay off twitter. It's horrible for my mental health!
Try it! Honestly the difference is amazing. Just delete the poxy app off your phone and away you go.

I’ve still got it on my work phone (which gets much less use) and I keep getting tempted into a wee scroll through Twitter whenever I get that phone out. Without fail I’m in a shitty mood for an hour or two afterwards.

Kind of annoyed with myself for wasting a lovely sunny day subliminally stressing about that stupid P1 variant.
 

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Last time we had lockdown with schools open, cases dropped, so there's no certainty that cases will rise. They might drop more slowly than they otherwise would have, but we're starting at a pretty low baseline, and primary school age kids currently have the lowest rate of infection of any age group, so are the lowest risk group to relax restrictions on.
Agree that we are at a low base. But should the lateral flow test results be added to national figures wouldn't you expect positive cases to go up. Twice weekly testing on about 10m kids. Figures are all heading in the right direction but I hope we don't get nervous about cases increasing. What's more important now is preventing admissions and hospitalizations.