Think it would make more sense to go for a 4-3-3 again similar to against Chelsea but bring Di Maria back to a more CM position.
If Falcao is fit then I would start him over RVP as we have Rooney back to captain the side.
Would choose Januzaj as he can push wide with Di Maria and have Fellaini and Blind stay more central to make it more of a 4-2-3-1 when appropriate.
De Gea
Rafael Smalling Rojo Shaw
Fellaini Blind Di Maria
Januzaj Rooney
Falcao/RVP
Subs: Lindegaard, Blackett, Jones/McNair, Herrera, Mata, Carrick, Falcao/RVP