Three at the back seems likely, but if Bailly isn't actually fit then I'm not sure Lindelof will be trusted (he's more likely to play against Benfica again). Smalling & Jones are both starting regardless. I don't think Martial & Rashford both start, it's one or the other. I was thinking the same for Mkhitaryan/Mata, especially if 343, though Lingard has given himself an argument to start over them. I feel as though Mkhitaryan and Mata have been poor for about a month now, since we strolled past Palace at Old Trafford at the end of September.
de Gea
Bailly Smalling Jones
Valencia Herrera Matic Young
Mkhitaryan Lukaku Rashford
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Romero; Lindelof, Darmian, Blind; Mata, Lingard; Martial
Might be a bit harsh on McTominay and Tuanzebe not getting in the squad at all, could replace Darmian/Blind but I think José would like them as an option in this kind of game.
Need to make a statement and win this one.