We need to win the midfield here, i would play 4-3-1-2 here, specially if Martial is ready.
--------------------DDG
--Dalot Varane Martinez Shaw
-McTominey Eriksen Casemiro
------------------Bruno
----------Rashford Martial
This system should be ideal against Tottenham if they attack with their 3-4-3 system. McTominey helping Dalot when then attack on that side while Casemiro does the same with Shaw on their side. Eriksen gets a free roll to diktade the play for his central deeper position while Bruno helps Rashford and Martial to press the defenders. Key will be to win a lot of the duels and first and second bal in the middle, get it fast to Eriksen/Bruno who needs to try to find Rashford behind the defenders or Martial who should be dropping and playing little more of a target player so we have time to move up our fullbacks, Eriksen, Bruno and one of Casemiro or McTominey.
If doesn't work after 60-65 min, we go back to our usual 4-2-3-1 by throwing in Ronaldo or Sancho (or both) and take out one of Casemiro/McTominey and Rashford/Martial.
But, we need to win this one, we can afford to play to many draws, we need to stick to the top 1-6 now while we have the chance and everybody is loosing points against each other.