Assume that Martial will join Mkhitaryan and Jones on the injury list, even if only precautionary. Practically every first-team player has had enough of a look in now to have some sort of sharpness in their game, right? It hasn't looked like it for the last week, but what can we do?
Valencia and Shaw are still first choice and have been at least average or above, so, I'd say they get 'rested' with Darmian and probably Rojo playing. Bailly might get dropped for a game since Blind has just missed two in a row. I'd like to see a midfield of Carrick, Herrera, and Pogba, but I'm not sure if we'll get there here. Schneiderlin needs to show a lot more, maybe he'll be asked to play this match to get more fit and actually try and do something. I think Zlatan and Rashford have to play and if we have those two on the pitch we can probably afford to play Memphis to see if he can get some confidence.
De Gea
Darmian Smalling Blind Rojo
Schneiderlin
Herrera Pogba
Rashford Ibrahimovic Memphis
---
Romero; Bailly, Fosu-Mensah; Carrick, Young, Mata; Rooney
Rooney will probably play, however. Though, I suppose we'd all prefer him to play here and miss the game after.