He's possibly the one guy that I'm not convinced we have adequate cover for or that it would be very noticeable if he's missing. If we go a 4-2-2-2, we can chop and change with at least 1 top quality option for each block (martial/rashford/cavani/Greenwood for attack, Bruno/Pogba/VdB for CAM, Telles/Shaw, Maguire/Tuanzebe/Lindelof)... Williams has to show he can compete with Wan Bissaka too of course, but at holding midfield, we really should be using 2 of Fred, McTominay or Matic. Only concern is I'm not sure McTominay and Matic can go together or if both need to pair with Fred. Van de Beek started off as a defensive mid for Ajax though, and his skill set would work fine there when needed, so maybe he's the guy to rotate with Fred next to Matic or McTominay, but in general it's crazy the turn around for Fred. Really struggled at first but turned into such an excellent ball winning midfielder who can play it into the more attacking players, but also himself being very good on the ball and pretty press resistant.
Has to start against Arsenal, and then rest him vs Istanbul.