I think we have a few players that are a tactical headache, and fitting them into the same side is difficult. One option that I'd explore is the italy model during the euros.
---------Cavani---------------------
-------Pogba-------------------------Sancho
Shaw------Mctominay----Bruno-------------------
Fred
Maguire-----Varane-----Wan Bissaka
When we have the ball, Shaw is the direct threat down the left, sancho (or greenwood) holds width on the right and makes the incisive runs into the box.
Wan Bissaka drops into a 3 which gives us more security against the counter, an easier passing option and plays to his strengths and particularly, his weaknesses going forward.
Pogba (or rashford/ronaldo) finds space infield or overloads the fullback where necessary, while bruno has the licence to break forward just like Barella does for Italy. His technical ability helps us in the build up, and his pressing ability combined with mctominay and Fred are our strongest asset when we lose the ball.
We can play a high line with the pace of varane and wan Bissaka, we get the most out of maguire when he has the security to step out with the ball. We limit wan bissaka's attacking involvement. We get the most from pogba. We get more from shaw's attacking potential.
We revert to a more traditional 4-2-3-1 when out of possession if the immediate press fails.