----------Ronaldo Cavani-------
Fernandes --------------Sancho
--------------Fred Vdb-------------
Shaw Maguire Varane Awb
-----------------Ddg-----------------
Rashford and Greenwood will generally be the first subs to be brought on but will also get a lot of starts on account of Cavani not always playing. He may use Ronaldo slightly less than Ole did, but he will still have him in the first eleven.
Mctominay and to a slightly lesser degree Matic will rotate with Fred and Vdb. I could see a role for Lingard as well, on account of his pressing and work rate ability.
Elanga and Mejbri could get some playing time in December and then perhaps go out on loan together with Amad - or stay, depending on circumstances. Elanga can play in four positions in this formation, Mejbri in three, Amad in one.
Martial and Pogba and a few others I think could be sold actually.
Overall I think we will see more rotation due to the higher pressing demands. The forwards in particular will be subbed often in order to be kept fresh.
Obviously in defense you have the obvious back-up options except for RB where I think there will be a new signing.
No new midfield signings right now because the club will wait on Rice and also because there will a renewed importance for Fred in particular, but also Vdb and Mctominay.
This is all (educated) speculation of course.