Blind and Fletcher absolutely shouldn't play in the same midfield. The one with Herrera and Di Maria flanking Daley works because as a combination they can help make up for Daley's relatively lower mobility/ dynamism levels. With Ander injured, there's a massive void of energy, creative ability and tenacity in the center of the park. Dunno if Carrick is fit but ideally we should take a measured approach with his fitness instead of throwing him straight in. A few more knocks and at his age, that could be curtains for his United career. Aside from Ander, we're also probably going to replace Rooney with Mata, so it's a double whammy in terms of work-rate vs an extremely energetic side.
We have a very similar player to Ander in the reserves. Might be a couple notches below in terms of awareness and the defter side of things, but Pereira can provide a lot of youthful energy, pressing ability and attacking impetus from the deep. Loads of people have commented on his suitability for a central midfield role and so far this season, it looks justified. Van Gaal has shown a reluctance for fitting square pegs into round holes and we have an almost like for like replacement in Andreas. Doesn't matter a lot if he's position ally wayward at times. Blind is an excellent organizer, you can see him barking instructions in game. He could lend a helping hand and keep Pereira in the right places.
If ever there was a time to give him a chance, it's now instead of chickening out in favor of experience. Also like mentioned before, Everton will be relatively tired. Let's take advantage of that and hound the ball instead of ceding control in midfield by being too cautious.
De Gea
Rafael - Jones - Rojo - Shaw
Blind
Pereira - Di Maria
Mata
Van Persie - Falcao