SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

Pexbo

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When you think how daft a decision that was it's mind blowing. Having an unnecessary mass household mixing event just before a need for full on lockdown. How many spreader events were caused.
It’s almost like they’ve been trying to edge us towards herd immunity without having the balls to admit it.
 

RoadTrip

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All those graphs they showed ... who is hammering them on why they didn’t act earlier? NOTHING is new in the last few days than since Christmas. And alas instead our journalists ask pointless questions about whether we will have kids in school before summer holidays when obviously no one knows the answer. Instead these questions should be about holding this Eton Mess to account.
 

B20

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We're going into hard lockdown in Denmark now because of the English Flu, which is projected to be the dominant strain by February if the curve doesn't break.

Meet 2021. Same as 2020.
 

DavidDeSchmikes

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Any restrictions next winter will likely only a fraction on what we had this time. Possibly limiting household mixing, things like that.

Another lockdown next winter would mean that the vaccine did pretty much feck all.
 

Brwned

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When you think how daft a decision that was it's mind blowing. Having an unnecessary mass household mixing event just before a need for full on lockdown. How many spreader events were caused.
Relatively few. If you take Public Health England's data from the last week of school in December, there were 260 potential outbreaks reported across the enitre week in educational settings, of which 200 were confirmed to have at least 1 case. 227 in care homes, 93 in hospitals, 174 in workplaces and other settings. In a week where 110,000 cases were reported, 200 outbreaks in educational settings is not a lot. And outbreaks at schools are disproportionately likely to be recorded, because they've had their own national school helpline since September to facilitate recording.

Super spreader events are much more likely to happen in other indoor settings with lots of adults, and an absolutely tiny proportion of cases are traced back to super spreader events in school. Super spreader events rely on someone with an exceptionally high viral load that spreads more easily. Kids are the least likely to be that. Household mixing of much smaller numbers in much more locations over Christmas will have had an impact several magnitudes larger, just because of how the disease spreads differently among adults and children.

More on super spreader events and children:

It is notable here that one child infected while displaying symptoms did not transmit the virus when visiting 3 schools.11 Clearly, children are less likely to develop severe complications from the disease, where a significant proportion are asymptomatic/or have subclinical symptoms12 and a meta-analysis shows those <20 years have an odds ratio of 0.56 for being an infected contact compared to those who are older, indicating children are less susceptible compared to adults.14 Evidence suggests children are not the primary source of infection in most household clusters as 9.7% of 31 transmission clusters identified were thought to have children as a paediatric index case.13 Further, transmission between children does not play a vital role in the formation of SSEs with explanations including lower levels of ACE2 present in the nasal epithelium of children compared to adults.
And a later study:

The role of children in the spread of SARS-CoV-2 remains highly controversial. To address this issue, we performed a meta-analysis of the published literature on household SARS-CoV-2 transmission clusters (n=213 from 12 countries). Only 8 (3.8%) transmission clusters were identified as having a paediatric index case. Asymptomatic index cases were associated with a lower secondary attack in contacts than symptomatic index cases (estimate risk ratio [RR], 0.17; 95% confidence interval [CI], 0.09-0.29). To determine the susceptibility of children to household infections the secondary attack rate (SAR) in paediatric household contacts was assessed. The secondary attack rate in paediatric household contacts was lower than in adult household contacts (RR, 0.62; 95% CI, 0.42-0.91). These data have important implications for the ongoing management of the COVID-19 pandemic, including potential vaccine prioritization strategies.

40-word summary In household transmission clusters of SARS-CoV-2 children are unlikely to be the index case. Children are also less likely than adults to be infected with SARS-CoV-2 from a family member.
 
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golden_blunder

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Can they not just make kids at all levels repeat the year so no one misses out?
I’m sure someone will tell me why that’s a bad idea
 

acnumber9

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Meanwhile Sage advisors say children between 12-16 are seven times more likely to bring the virus into households than anybody else.

https://www.google.co.uk/amp/s/inew...in-virus-sage-adviser-mark-walport-815659/amp

He added that the new coronavirus variant is “transmitting more readily in younger age groups”, but does not appear to be more resistant to the vaccine.

“We know that transmission occurs within schools, we know that a person between 12 and 16 is seven times more likely than others in a household to bring the infection into a household.

“We know that there was a small dip in transmission in school children after the half term,” he said.
 

Relevated

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Can they not just make kids at all levels repeat the year so no one misses out?
I’m sure someone will tell me why that’s a bad idea
For these decisions there is a lot of admin and red tape involved. Even though it should be, it isn't simple enough because anyone along the way can pop up and say they disagree with it. You have to get permission from various departments and then a year later Boris implements it for the year after.
 

Pogue Mahone

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Buster15

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“Alas, flubble bubble, errr schools errr and important to errr should stay open but waffle toffle the new lockdown is err thank you I hope that answers your question. Yes, Laura next please“
After that, he again said 'schools are safe'
That is his problem. He just doesn't understand what the hell is going on.
 

acnumber9

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Have they changed tune recently or am I imagining that they previously said school kids aren't an issue
Various different studies will say various different things. And in fairness to the scientists involved it’s an ever changing picture. That’s why it’s dangerous to state things as fact when it’s anything but.
 

Fluctuation0161

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Personally I think opening shops for Christmas and opening up the household mixing was always going to lead to a spike that required a lockdown in January, and it was a stupid trade-off for the government to make and the public to take up. Short-term gain for long-term pain is rarely a good strategy.

It's undoubtedly true though that the new strain has had an impact, and has significantly changed their plans. Without the new strain we may have repeated the "circuit-breaker" from November: stabilise cases across the country and bring the worst areas back into levels the government think are manageable. I don't think they would have considered another lockdown for an indefinite period to even be a last resort if it wasn't for this variant.
Didn't the new UK variant mutate in the conditions created by this government's early lax policies? High numbers = more chance of a mutated strain.

Many areas around London were put in tier 2 when tier 3 should've applied. The regional lockdown was a farce to appease the anti lockdown mps in the Tory party.
 

acnumber9

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I didn’t realise that they’re planning to reopen secondary schools (only keeping primary schools closed) in the UK. That seems absolutely mad.
Neither did I. It seems absolutely insane to me but I’d be surprised if it actually happened. I’m not sure that is accurate. It’s not in any other news that I’ve seen.
 

Pogue Mahone

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Can they not just make kids at all levels repeat the year so no one misses out?
I’m sure someone will tell me why that’s a bad idea
It would feck up third level education, who rely on the schools to provide them with new students each year. And you can’t make all third level students repeat a year because that would decimate the work force (no junior doctors etc)
 

golden_blunder

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For these decisions there is a lot of admin and red tape involved. Even though it should be, it isn't simple enough because anyone along the way can pop up and say they disagree with it. You have to get permission from various departments and then a year later Boris implements it for the year after.
Just seems to me that it would be fair to all the kids and solve some of the concerns
 

Relevated

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Covid is so mad. It messes up things at various levels. I wonder how many deaths we'd have been if we carried on as normal with no restrictions
 

golden_blunder

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It would feck up third level education, who rely on the schools to provide them with new students each year. And you can’t make all third level students repeat a year because that would decimate the work force (no junior doctors etc)
Could third level students not be stretched out by adding another year of work experience?
 

F-Red

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Didn't the new UK variant mutate in the conditions created by this government's early lax policies? High numbers = more chance of a mutated strain.

Many areas around London were put in tier 2 when tier 3 should've applied. The regional lockdown was a farce to appease the anti lockdown mps in the Tory party.
I don't think a virus has a political leaning, as much as you would like it to.
 

ha_rooney

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I didn’t realise that they’re planning to reopen secondary schools (only keeping primary schools closed) in the UK. That seems absolutely mad.
Neither did I. It seems absolutely insane to me but I’d be surprised if it actually happened. I’m not sure that is accurate. It’s not in any other news that I’ve seen.
That article is before his announcement yesterday. All schools are closed for all kids except children of key workers & the most vulnerable
 

JPRouve

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The Prime Minister of Great Britain ladies and gentlemen...

To be honest I feel for him. Years ago I was supposed to read Robinson Crusoe and do a presentation, boy did I struggle during that presentation.
 

Pogue Mahone

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So latest analysis in Ireland has only 20% of samples as the “UK variant”. In a way, I find that reassuring. It shows that you can have an astronomical surge (quickest increase in cases per 100k in Europe, I think?) without being fuelled primarily by increased transmissibility of the virus.

Which means it’s still possible that the surge (in Ireland and the UK) is mainly driven by non-virus factors and the measures that worked once can work again.
 

Pexbo

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Just had a notification on the NHS app that I have to isolate for 4 days. Does that mean someone tested positive 6 days ago and only just entered the result?
 

jojojo

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Just had a notification on the NHS app that I have to isolate for 4 days. Does that mean someone tested positive 6 days ago and only just entered the result?
More likely that it's somebody who last met you 6 days ago. Test/trace asks for contacts from 2 days before symptoms through to when the person isolated.

Their test request could easily be 4 days ago. test 2 days ago, result today.
 

Pexbo

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More likely that it's somebody who last met you 6 days ago. Test/trace asks for contacts from 2 days before symptoms through to when the person isolated.

Their test request could easily be 4 days ago. test 2 days ago, result today.
Hmm I guess that could make sense then. Cheers
 

Brwned

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USA are looking at halving the Moderna dosage now as well.
Very different situation, surely?

They want to use a dosage that was tested in a phase 2 trial, based on data on the immune response that dosage generates under those specific circumstances. And the change in dosing would be based on conducting a follow-up study to test their hypotheses to get specific approval from the regulator.
In order to provide the F.D.A. with the kind of data it would need to approve a change in dosing, scientists must first study blood samples from patients who participated in the Phase III trial to determine precisely what immune response correlates with protection against Covid-19.

Then, Dr. Mascola said, researchers would have to either look back at patients from the Phase II trial, or conduct a new one, to demonstrate that patients who received the 50 milligram dose developed the threshold immune response. If the results looked promising, he said, “all this then needs to be put together as a data package for review and discussion with F.D.A.”
The comparison to Pfizer would be if the UK decided to use a 10μg dose rather than a 30μg dose, which they tested in phase II as well. They're not doing that because the evidence suggests it wouldn't be very effective.

The UK's decision to delay dosing is not at all equivalent because the same evidence doesn't exist. They didn't experiment with different intervals and they aren't conducting a validation study for their hypothesis. They're just running a live trial on the population on the assumption their hypothesis is correct, and if it isn't, the downsides that will follow are thought to be smaller than the current risk of not doing it. It is an act of desperation, I'm not sure why you keep trying to sugar coat it with speculation that it must be based on something real. They can't invent the data so they have to go with their best guess. It doesn't change the fact it's a guess.