Is it their best chance though? This is what I'm saying. In the seasons City have been in the CL, this is shaping up to be a very strong quarter-finals. If things go as they should, there's not a single team that'll be there that won't be a significant challenge for them (and it's not particularly unreasonable to think they could lose by two in Monaco anyway).
Wolfsburg and Benfica were both there last season, Porto and a weaker Monaco the year before, a Moyes-led United the year before that, Galatasaray and Malaga before that.