Not sure I've ever said this, but I'd start Fellaini. If Schneiderlin is out, doesn't his make the most sense on form and health:
----------------Martial------------
Young/Lingard--------------Mata
-------Fellaini------Herrera-------
------------Schweinsteiger--------
Rojo---Jones-----Smalling--Darmian
----------------De Gea------------
Schweinsteiger should have a bit of time to pick passes with Herrera and Fellaini's mobility in that area.
Alternatively, Pereira could play Fellaini's role, which would keep us in that 4-3-3 that might help a bit in terms of fluidity compared to how we look in the 4-2-3-1, and have the added virtue of being exciting, improving our passing ability on the ground and giving good experience to a youth player.