Personally, I would go:
----------------De Gea--------------
-Jones---Smalling--Vidic---Rafael--
--------Carrick---Cleverley------
-----------Rooney----------------
--Shinji---Persie----Welbeck--
Rooney is essentially a midfielder for this game, with Shinji tucking in too. Persie to hold up and Welbeck to spring the counter.
----------------De Gea--------------
-Jones---Smalling--Vidic---Rafael--
--------Carrick---Cleverley------
-----------Rooney----------------
--Shinji---Persie----Welbeck--
Rooney is essentially a midfielder for this game, with Shinji tucking in too. Persie to hold up and Welbeck to spring the counter.