NinjaFletch
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Quite the opposite! They couldn't have expected the vaccine to be 90% effective, that's huge. Light at the end of the tunnel!
Does anyone know what happens to the candidates who got the vaccine first dose but tested positive within 28 days?Upon the conclusion of those discussions, the evaluable case count reached 94 and the DMC performed its first analysis on all cases
The case split between vaccinated individuals and those who received the placebo indicates a vaccine efficacy rate above 90%, at 7 days after the second dose. This means that protection is achieved 28 days after the initiation of the vaccination, which consists of a 2-dose schedule.
Good question and it’s impossible to know from that press release. These press releases always highlight the good stuff and gloss over the bad stuff but the efficacy they’re talking about is exciting.90% sounds great..
the press release - https://www.pfizer.com/news/press-r...d-biontech-announce-vaccine-candidate-against
Does anyone know what happens to the candidates who got the vaccine first dose but tested positive within 28 days?
Does that number get thrown out? Or do they count in the 94 cases they evaluated? If they are counted, wouldnt that skew the efficacy data?
oxford st and piccadily circus were completely dead when i was there the other night, a few people around but nothing like usual. no pubs open. maybe out of central things are more laxZero signs of lockdown being in place in London. Pubs are openly selling beer in plastic cups with large crowds gathering to sit with friends outside. Food stalls are all open, as are markets. It’s a bit mental.
If it was single digit temperatures with rain that might change. Weather like this and there’s no way people comply.
The storage temperatures for these mean a lot of countries wont be using the mRNA vaccines. I dont think India has the infrastructure to transport and store them at the needed temperature.Good question and it’s impossible to know from that press release. These press releases always highlight the good stuff and gloss over the bad stuff but the efficacy they’re talking about is exciting.
Although the fact this vaccine needs two doses is a bummer. They’re talking about manufacturing 1.5bn doses next year. Which means half that number of people can get vaccinated.
I can imagine that being true. Larger police presence there too. It’s a pretty guff part of London though. With retail closed you’re not going to have many people pulled from their suburb to go there.oxford st and piccadily circus were completely dead when i was there the other night, a few people around but nothing like usual. no pubs open. maybe out of central things are more lax
That graph is Zoom shares.No idea why. The plan has always been to use both early next year. The Oxford one may even be one dose and doesn’t require the storage difficulties the Pfizer one does. If I was into stocks I’d be getting on that...
Oh right! I thought it was AZ as in AstraZenecaThat graph is Zoom shares.
So did I at first!Oh right! I thought it was AZ as in AstraZeneca
Doesnt Pfizer plan on using temperature controlled boxes to overcome the lack of a cold chain in developing nations?The storage temperatures for these mean a lot of countries wont be using the mRNA vaccines. I dont think India has the infrastructure to transport and store them at the needed temperature.
I said this a week ago by the way. My wife is involved in helping the storage of the vaccines too - she mentioned at the time they are to be stored at liquid nitrogen levels or something, so it's creating an issue for storage at GP practices. Hospitals are working on storing on their side and delivering but they need to be used within 5 days of delivery.Covid vaccine programme in UK to arrive in December apparently, front line workers and those over 80 are prioritised.
Take with a pinch of salt - this is from a CCG meeting for GP surgeries so it's coming from a rep. It was apparently kept under wrap by NHSE for a while.
Nope. 94. They are waiting for 164 to get enough data to submit for an EUA I thinkVery good news and potentially great news for mRNA vaccines as a novel technology too
But I want to read a full study or report, annoyed that an announcement of this magnitude had a brief press release
But going by the press release
-43,538 participants so far, 38,955 have received a second dose, trial started on july 27th
-total of 164 confirmed COVID-19 cases have accrued since then (?presumably 90% in the placebo or just one vaccine arm but no breakdown of this)
-still analysing to see if prevents against severe covid disease
-data going to be submitted for scientific peer-review publication but no timeframe mentioned
Efficacy of more than 90% to be honest would be pretty extraordinary if true
I didn't know that. would be great if they could find a way.. especially if this works considerably better than the more traditional vaccines.Doesnt Pfizer plan on using temperature controlled boxes to overcome the lack of a cold chain in developing nations?
Stats always melt my head but that does seem like a very low number of events so you’d wonder about the statistical significance of their findings. Next data cut will be importantVery good news and potentially great news for mRNA vaccines as a novel technology too
But I want to read a full study or report, annoyed that an announcement of this magnitude had a brief press release
But going by the press release
-43,538 participants so far, 38,955 have received a second dose, trial started on july 27th
-total of 164 confirmed COVID-19 cases have accrued since then (?presumably 90% in the placebo or just one vaccine arm but no breakdown of this)
-still analysing to see if prevents against severe covid disease
-data going to be submitted for scientific peer-review publication but no timeframe mentioned
Efficacy of more than 90% to be honest would be pretty extraordinary if true
With any vaccine you expect there to not be total 100% immunity due to various factors like age, g3netics etc. But the main idea is that if it protects enough people so that transmission rates in the community go down, it is very unlikely for those in whom the vaccine doesn't work to catch the disease, simply because there is now an acquired herd immunity to stop transmission.Nice news for a change.
But question from an utter dimwit...
If it's got a 90% success rate, that would still mean 10% are still vulnerable to the disease. Now, this may be an unfounded assumption, but surely those 10% who are still vulnerable to the disease post-vaccine are likely to be those who suffer the worst from Covid?
Going off the assumption that ~1.5-2% (?) of people with Covid actually require medical care when suffering from the disease in a world where a vaccine isn't available, does this vaccine merely protect those against the disease who didn't really require protection to begin with? Also, that 10% could still see hospitals/healthcare infrastructure hugely overwhelmed during a strong surge of cases.
Given the whole point of lockdown is to avoid overwhelming key infrastructure services, does a vaccine with a 90% success rate do that?
Again, I cannot emphasise enough how little I know about this, so any input one way or another would be appreciated!
There’s actually a good chance the opposite is the case. The vaccine might give partial protection to some people, so they catch the virus but don’t get very sick. We won’t know until they release all the data on those 94 cases and the individual outcomes.Nice news for a change.
But question from an utter dimwit...
If it's got a 90% success rate, that would still mean 10% are still vulnerable to the disease. Now, this may be an unfounded assumption, but surely those 10% who are still vulnerable to the disease post-vaccine are likely to be those who suffer the worst from Covid?
Going off the assumption that ~1.5-2% (?) of people with Covid actually require medical care when suffering from the disease in a world where a vaccine isn't available, does this vaccine merely protect those against the disease who didn't really require protection to begin with? Also, that 10% could still see hospitals/healthcare infrastructure hugely overwhelmed during a strong surge of cases.
Given the whole point of lockdown is to avoid overwhelming key infrastructure services, does a vaccine with a 90% success rate do that?
Again, I cannot emphasise enough how little I know about this, so any input one way or another would be appreciated!
How can long term effects be known when it is such a new development?How can they make a vaccine so quick is it safe!
https://www.google.com/amp/s/www.ws...vaccination-distribution-campaign-11603272614I didn't know that. would be great if they could find a way.. especially if this works considerably better than the more traditional vaccines.
Last I read (a couple of months back), it was basically saying India would be waiting for the traditional vaccine and not the mRNA ones .
Indeed that's my concern too, depends of where those tests were, I'd be more convinced if they tested it in a place thats a hotbed for covid community transmissions with higher covid incidences in the placebo group than what's reported to be more certainStats always melt my head but that does seem like a very low number of events so you’d wonder about the statistical significance of their findings. Next data cut will be important
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Since you seem to know a bit about this - what are the chances of this being available in India? Is it a no-go even in the metros?Even if they file for an EUA by end of Nov, they wont get approval this year.. so they better have some huge storage facilities for those if they are ramping up production right now.
If you're healthy, under 50 and not a frontline worker its unlikely you'll get vaccinated in 2021.Since you seem to know a bit about this - what are the chances of this being available in India? Is it a no-go even in the metros?
I really don't know much.. Seen a few interviews on the JAMA(The Journal of the American Medical Association) youtube channel .. One was with someone on the panel which will be advising the FDA about the vaccines and he was talking about the process.. said the FDA wont give out a licence anytime soon.. need long term data.. so anything that'll be approved will now will get an Emergency Use Authorization (EUA).Since you seem to know a bit about this - what are the chances of this being available in India? Is it a no-go even in the metros?