One of McFred will get dropped, it's just a matter of which one.
I'd go with:
DDG
Malacia Maguire Martinez Shaw
Eriksen Fred
Bruno
Sancho Ronaldo Rashford
Malacia because he can't be any worse than Dalot, despite his preference for playing at LB.
I'd opt for Fred over Mctominay as he is the more accomplished DM positionally, and the latter would be more impactful from the bench if/when defending a lead. It's purely a matter of preference though, as there isn't much between them.
Oh and we'll win this one today.